Nan Ru1, Sean Shih-Yao Liu2, Yuxing Bai3, Song Li4, Yunfeng Liu5, Xiaoxia Wei6. 1. Lecturer, Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. 2. Associate professor; director, Mineralized Tissues and Histology Research Laboratory; and director, Orthodontic Fellowship Program, Department of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, Indianapolis, Ind. 3. Professor, Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. Electronic address: byuxing@263.net. 4. Professor, Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. 5. Associate professor, Key Laboratory of Equipment & Manufacturing, Zhejiang University of Technology, Hangzhou, China. 6. Associate professor, Department of Orthodontics, School of Stomatology, Zhengzhou University, Zhengzhou, China.
Abstract
INTRODUCTION: BoneCeramic (Straumann, Basel, Switzerland) can regenerate bone in alveolar defects after tooth extraction, but it is unknown whether it is feasible to move a tooth through BoneCeramic grafting sites. The objective of this study was to investigate 3-dimensional real-time root resorption and bone responses in grafted sites during orthodontic tooth movement. METHODS: Sixty 5-week-old rats were randomly assigned to 3 groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss; Geistlich Pharma, Wolhusen, Switzerland), or no graft, after the extraction of the maxillary left first molar. After 4 weeks, the maxillary left second molar was moved into the extraction site for 28 days. Dynamic bone microstructures and root resorption were evaluated using in-vivo microcomputed tomography. Stress distribution and corresponding tissue responses were examined by the finite element method and histology. Mixed model analysis of variance was performed to compare the differences among time points with Bonferroni post-hoc tests at the significance level of P <0.05. RESULTS: The BoneCeramic group had the least amount of tooth movement and root resorption volumes and craters, and the highest bone volume fraction, trabecular number, and mean trabecular thickness, followed by the Bio-Oss and the control groups. The highest stress accumulated in the cervical region of the mesial roots. CONCLUSIONS: BoneCeramic has better osteoconductive potential and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction sites.
INTRODUCTION: BoneCeramic (Straumann, Basel, Switzerland) can regenerate bone in alveolar defects after tooth extraction, but it is unknown whether it is feasible to move a tooth through BoneCeramic grafting sites. The objective of this study was to investigate 3-dimensional real-time root resorption and bone responses in grafted sites during orthodontic tooth movement. METHODS: Sixty 5-week-old rats were randomly assigned to 3 groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss; Geistlich Pharma, Wolhusen, Switzerland), or no graft, after the extraction of the maxillary left first molar. After 4 weeks, the maxillary left second molar was moved into the extraction site for 28 days. Dynamic bone microstructures and root resorption were evaluated using in-vivo microcomputed tomography. Stress distribution and corresponding tissue responses were examined by the finite element method and histology. Mixed model analysis of variance was performed to compare the differences among time points with Bonferroni post-hoc tests at the significance level of P <0.05. RESULTS: The BoneCeramic group had the least amount of tooth movement and root resorption volumes and craters, and the highest bone volume fraction, trabecular number, and mean trabecular thickness, followed by the Bio-Oss and the control groups. The highest stress accumulated in the cervical region of the mesial roots. CONCLUSIONS: BoneCeramic has better osteoconductive potential and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction sites.
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Sachin Chhatwani; Benita Hermanns-Sachweh; Felix Gremse; Frank Hölzle; Gholamreza Danesh; Ali Modabber Journal: Clin Oral Investig Date: 2022-05-14 Impact factor: 3.606
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Benita Hermanns-Sachweh; Felix Gremse; Frank Hölzle; Gholamreza Danesh; Ali Modabber Journal: Sci Rep Date: 2021-06-30 Impact factor: 4.379
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Felix Gremse; Florian Peters; Gholamreza Danesh; Frank Hölzle; Ali Modabber Journal: Sci Rep Date: 2020-11-26 Impact factor: 4.379