M Monseu1, S Dubois2, J Boursier3, C Aubé4, F Gagnadoux5, G Lefthériotis6, P-H Ducluzeau7. 1. Department of Internal Medicine, CHU Tours, 2, boulevard Tonnellé, Tours, France. Electronic address: mathilde.monseu@ens-lyon.org. 2. Department of Diabetology, CHU, Angers, France. Electronic address: sedubois@chu-angers.fr. 3. Department of Hepatology, CHU, Angers, France. Electronic address: jeboursier@chu-angers.fr. 4. Department of Radiology, CHU, Angers, France. Electronic address: chaube@chu-angers.fr. 5. Department of Pneumology, CHU, Angers, France. Electronic address: frgagnadoux@chu-angers.fr. 6. Department of Vascular Explorations, CHU, Angers, France. Electronic address: geleftheriotis@chu-angers.fr. 7. Inserm UMR1069, "Nutrition, Growth and Cancer", CHRU Bretonneau, University of Tours, 37044 Tours, France. Electronic address: ph.ducluzeau@chu-tours.fr.
Abstract
AIM: This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS: Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. They then underwent a thorough metabolic and cardiovascular evaluation, including arterial stiffness, atherosclerotic plaques, homoeostasis model assessment for insulin resistance (HOMA-IR) indices and OPG. VAT and LF content were measured by magnetic resonance imaging (MRI). Ultrasound examination of arteries and arterial stiffness were recorded, and age- and gender-adjusted paired correlations calculated. RESULTS: Body mass index, waist circumference and MRI-derived VAT correlated with OPG, whereas abdominal subcutaneous fat did not. OPG levels were strongly correlated with LF content (r=0.25, P=0.003), liver markers such as alanine aminotransferase (r=0.39, P<0.001) and HOMA-IR index (r=0.39, P<0.0001). Plasma OPG also correlated with arterial stiffness and the number of atherosclerotic sites. CONCLUSION: Plasma OPG levels are positively associated with both liver markers and increased LF content, but not with subcutaneous fat in dysmetabolic men. These findings suggest that elevated OPG levels may play a role in the link between fatty liver disease and enhanced cardiovascular risk.
AIM: This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS: Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. They then underwent a thorough metabolic and cardiovascular evaluation, including arterial stiffness, atherosclerotic plaques, homoeostasis model assessment for insulin resistance (HOMA-IR) indices and OPG. VAT and LF content were measured by magnetic resonance imaging (MRI). Ultrasound examination of arteries and arterial stiffness were recorded, and age- and gender-adjusted paired correlations calculated. RESULTS: Body mass index, waist circumference and MRI-derived VAT correlated with OPG, whereas abdominal subcutaneous fat did not. OPG levels were strongly correlated with LF content (r=0.25, P=0.003), liver markers such as alanine aminotransferase (r=0.39, P<0.001) and HOMA-IR index (r=0.39, P<0.0001). Plasma OPG also correlated with arterial stiffness and the number of atherosclerotic sites. CONCLUSION: Plasma OPG levels are positively associated with both liver markers and increased LF content, but not with subcutaneous fat in dysmetabolicmen. These findings suggest that elevated OPG levels may play a role in the link between fatty liver disease and enhanced cardiovascular risk.
Authors: Zachary P Fricker; Alison Pedley; Joseph M Massaro; Ramachandran S Vasan; Udo Hoffmann; Emelia J Benjamin; Michelle T Long Journal: Clin Gastroenterol Hepatol Date: 2018-11-23 Impact factor: 11.382
Authors: Carmen G Barbu; Andreea L Arsene; Suzana Florea; Alice Albu; Anca Sirbu; Sorina Martin; Alina C Nicolae; George T A Burcea-Dragomiroiu; Daniela E Popa; Bruno S Velescu; Ion B Dumitrescu; Niculina Mitrea; Doina Draganescu; Dumitru Lupuliasa; Demetrios A Spandidos; Aristides M Tsatsakis; Cristina M Dragoi; Simona Fica Journal: Mol Med Rep Date: 2017-08-28 Impact factor: 2.952
Authors: Christopher Brampton; Viola Pomozi; Li-Hsieh Chen; Ailea Apana; Sara McCurdy; Janna Zoll; William A Boisvert; Gilles Lambert; Daniel Henrion; Simon Blanchard; Sheree Kuo; Georges Leftheriotis; Ludovic Martin; Olivier Le Saux Journal: Sci Rep Date: 2021-02-16 Impact factor: 4.379