| Literature DB >> 27015302 |
James E Hughes Hallett1, Brendan D Manning2.
Abstract
The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.Entities:
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Year: 2016 PMID： 27015302 DOI： 10.1016/j.cell.2016.03.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582