Celia Bustos-Brito1, Adolfo Andrade-Cetto2, Juan David Giraldo-Aguirre1, Angelina Daniela Moreno-Vargas3, Leovigildo Quijano1. 1. Instituto de Química, Universidad Nacional Autónoma de México, 04510 México CD. MX., Mexico. 2. Laboratorio de Etnofarmacología, Facultad de Ciencias, Universidad Nacional Autónoma de México, 04510 México CD. MX., Mexico. Electronic address: aac@ciencias.unam.mx. 3. Laboratorio de Etnofarmacología, Facultad de Ciencias, Universidad Nacional Autónoma de México, 04510 México CD. MX., Mexico.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Type 2 diabetes is characterized by tissue resistance to the action of insulin combined with a relative deficiency in insulin secretion. In Mexico, medicinal plants have traditionally been used to control the disease; in this work, we investigate the hypoglycemic effect of Ageratina petiolaris, a plant used in Mexico for the treatment of diabetes. METHODS: The hypoglycemic effects of aqueous and methanolic extracts prepared from aerial parts of Ageratina petiolaris in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats were assessed. An oral administration of the water extract at doses of 40 and 160mg/kg and of the methanol extract at doses of 67 and 268mg/kg were evaluated. Furthermore, the water extract at 160mg/kg was evaluated under an Oral Glucose Tolerance Test. RESULTS: The tested extracts were able to reduce the increase in blood glucose level at three hours after administration. l-chiro-inositol and chlorogenic acid were isolated as important constituents of the plant, they were identified in both extracts along with other constituents. CONCLUSIONS: The results presented here demonstrate that the main components in the aqueous extract of Ageratina petiolaris are chlorogenic acid and l-chiro-inositol, the last one with significant hypoglycemic activity, these results support the traditional use of this plant for the treatment of type 2 diabetes.
ETHNOPHARMACOLOGICAL RELEVANCE: Type 2 diabetes is characterized by tissue resistance to the action of insulin combined with a relative deficiency in insulin secretion. In Mexico, medicinal plants have traditionally been used to control the disease; in this work, we investigate the hypoglycemic effect of Ageratina petiolaris, a plant used in Mexico for the treatment of diabetes. METHODS: The hypoglycemic effects of aqueous and methanolic extracts prepared from aerial parts of Ageratina petiolaris in streptozotocin-nicotinamide (STZ-NA) induced diabeticrats were assessed. An oral administration of the water extract at doses of 40 and 160mg/kg and of the methanol extract at doses of 67 and 268mg/kg were evaluated. Furthermore, the water extract at 160mg/kg was evaluated under an Oral Glucose Tolerance Test. RESULTS: The tested extracts were able to reduce the increase in blood glucose level at three hours after administration. l-chiro-inositol and chlorogenic acid were isolated as important constituents of the plant, they were identified in both extracts along with other constituents. CONCLUSIONS: The results presented here demonstrate that the main components in the aqueous extract of Ageratina petiolaris are chlorogenic acid and l-chiro-inositol, the last one with significant hypoglycemic activity, these results support the traditional use of this plant for the treatment of type 2 diabetes.
Authors: Adolfo Andrade-Cetto; Elda Carola Cruz; Christian Alan Cabello-Hernández; René Cárdenas-Vázquez Journal: Evid Based Complement Alternat Med Date: 2019-01-01 Impact factor: 2.629