Epigenetic Control of Skin Re-Epithelialization: the NF-kB/JMJD3 Connection.

Major changes in gene expression must occur at wound site to establish the cellular responses required for rapid healing. Although epigenetic remodeling plays a role in gene modulation, the mechanisms responsible for epigenetic regulation during healing are largely unknown. The study from Na et al. sheds light on the role of histone demethylase Jumonji domain-containing protein D3 in promoting keratinocyte function after injury, and it links Jumonji domain-containing protein D3-dependent gene expression to NK-kB activity.