Literature DB >> 27012539

The Ties that Bind (the Igh Locus).

Michael S Krangel1.   

Abstract

Immunoglobulin heavy-chain locus V(D)J recombination requires a 3D chromatin organization which permits widely distributed variable (V) gene segments to contact distant diversity (D) and joining (J) gene segments. A recent study has identified key nodes in the locus interactome, paving the way for new molecular insights into how the locus is configured for recombination.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  V(D)J recombination; chromatin; chromosome conformation capture; immunoglobulin heavy chain

Mesh：

Substances：

Year:  2016        PMID： 27012539      PMCID： PMC4842146          DOI： 10.1016/j.tig.2016.03.003

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  10 in total

Review 1.  A decade of 3C technologies: insights into nuclear organization.

Authors:  Elzo de Wit; Wouter de Laat
Journal:  Genes Dev       Date:  2012-01-01       Impact factor: 11.361

2.  The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

Authors:  Suchit Jhunjhunwala; Menno C van Zelm; Mandy M Peak; Steve Cutchin; Roy Riblet; Jacques J M van Dongen; Frank G Grosveld; Tobias A Knoch; Cornelis Murre
Journal:  Cell       Date:  2008-04-18       Impact factor: 41.582

3.  Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus.

Authors:  Changying Guo; Tatiana Gerasimova; Haiping Hao; Irina Ivanova; Tirtha Chakraborty; Roza Selimyan; Eugene M Oltz; Ranjan Sen
Journal:  Cell       Date:  2011-10-06       Impact factor: 41.582

Review 4.  CTCF: an architectural protein bridging genome topology and function.

Authors:  Chin-Tong Ong; Victor G Corces
Journal:  Nat Rev Genet       Date:  2014-03-11       Impact factor: 53.242

Review 5.  Recombination centres and the orchestration of V(D)J recombination.

Authors:  David G Schatz; Yanhong Ji
Journal:  Nat Rev Immunol       Date:  2011-03-11       Impact factor: 53.106

Review 6.  The hierarchy of the 3D genome.

Authors:  Johan H Gibcus; Job Dekker
Journal:  Mol Cell       Date:  2013-03-07       Impact factor: 17.970

7.  Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire.

Authors:  Lindsey Montefiori; Robert Wuerffel; Damian Roqueiro; Bryan Lajoie; Changying Guo; Tatiana Gerasimova; Supriyo De; William Wood; Kevin G Becker; Job Dekker; Jie Liang; Ranjan Sen; Amy L Kenter
Journal:  Cell Rep       Date:  2016-01-21       Impact factor: 9.423

8.  CTCF-binding elements mediate control of V(D)J recombination.

Authors:  Chunguang Guo; Hye Suk Yoon; Andrew Franklin; Suvi Jain; Anja Ebert; Hwei-Ling Cheng; Erica Hansen; Orion Despo; Claudia Bossen; Christian Vettermann; Jamie G Bates; Nicholas Richards; Darienne Myers; Harin Patel; Michael Gallagher; Mark S Schlissel; Cornelis Murre; Meinrad Busslinger; Cosmas C Giallourakis; Frederick W Alt
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

9.  Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

Authors:  Jasna Medvedovic; Anja Ebert; Hiromi Tagoh; Ido M Tamir; Tanja A Schwickert; Maria Novatchkova; Qiong Sun; Pim J Huis In 't Veld; Chunguang Guo; Hye Suk Yoon; Yves Denizot; Sjoerd J B Holwerda; Wouter de Laat; Michel Cogné; Yang Shi; Frederick W Alt; Meinrad Busslinger
Journal:  Immunity       Date:  2013-08-22       Impact factor: 31.745

10.  A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation.

Authors:  Tatiana Gerasimova; Changying Guo; Amalendu Ghosh; Xiang Qiu; Lindsey Montefiori; Jiyoti Verma-Gaur; Nancy M Choi; Ann J Feeney; Ranjan Sen
Journal:  Genes Dev       Date:  2015-08-15       Impact factor: 11.361
  10 in total

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