Literature DB >> 27012304

Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients.

Giulio Geraci1, Giuseppe Mulè2, Manuela Mogavero2, Calogero Geraci2, Emilio Nardi2, Santina Cottone2.   

Abstract

The role of vascular renal changes in mediating the association between serum uric acid (SUA) and renal damage is unclear. The purposes of this study were to investigate the relationship between SUA and renal resistive index (RRI), assessed by duplex Doppler ultrasonography, and to assess whether hemodynamic renal changes may explain the association between SUA and renal damage in hypertensive patients. A total of 530 hypertensive patients with and without chronic kidney disease were enrolled and divided into SUA tertiles based on sex-specific cutoff values. RRI and albuminuria were greater and glomerular filtration rate (GFR) was lower in the uppermost SUA tertile patients when compared with those in the lowest tertiles (all P<.001). Moreover, SUA strongly correlated with RRI (P<.001) in all patients. However, RRI did not seem to explain the relationship between SUA and renal damage, and GFR significantly related with SUA in the overall population (P<.001) even after adjustment for RRI. ©2016 Wiley Periodicals, Inc.

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Year:  2016        PMID： 27012304      PMCID： PMC8031671          DOI： 10.1111/jch.12812

Source DB:  PubMed          Journal:  J Clin Hypertens (Greenwich)        ISSN： 1524-6175            Impact factor:   3.738


  34 in total

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Journal:  Am J Nephrol       Date:  2005-08-19       Impact factor: 3.754

2.  Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patients with and without impaired renal function.

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3.  Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.

Authors:  M Mazzali; J Hughes; Y G Kim; J A Jefferson; D H Kang; K L Gordon; H Y Lan; S Kivlighn; R J Johnson
Journal:  Hypertension       Date:  2001-11       Impact factor: 10.190

4.  Serum uric acid levels and renal damage in hyperuricemic hypertensive patients treated with renin-angiotensin system blockers.

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5.  Mild hyperuricemia induces glomerular hypertension in normal rats.

Authors:  Laura G Sánchez-Lozada; Edilia Tapia; Carmen Avila-Casado; Virgilia Soto; Martha Franco; José Santamaría; Takahiko Nakagawa; Bernardo Rodríguez-Iturbe; Richard J Johnson; Jaime Herrera-Acosta
Journal:  Am J Physiol Renal Physiol       Date:  2002-11

6.  Intrinsic renal disease leading to abnormal urate excretion.

Authors:  R E Rieselbach; T H Steele
Journal:  Nephron       Date:  1975       Impact factor: 2.847

7.  Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study.

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9.  Uric acid level has a U-shaped association with loss of kidney function in healthy people: a prospective cohort study.

Authors:  Eiichiro Kanda; Toshitaka Muneyuki; Yoshihiko Kanno; Kaname Suwa; Kei Nakajima
Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240

10.  The association of albuminuria with tubular reabsorption of uric acid: results from a general population cohort.

Authors:  Lieneke Scheven; Michel M Joosten; Paul E de Jong; Stephan J L Bakker; Ron T Gansevoort
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  9 in total

1.  Chronological renal resistive index increases related to atherosclerotic factors, and effect of renin-angiotensin system inhibitors.

Authors:  Yoshito Yamaguchi; Fuyuko Akagaki; Aya Nakamori; Toshihiro Sugiura
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2.  The effects of topiroxostat on vascular function in patients with hyperuricemia.

Authors:  Shingo Higa; Daisuke Shima; Naoko Tomitani; Yoko Fujimoto; Kazuomi Kario
Journal:  J Clin Hypertens (Greenwich)       Date:  2019-09-26       Impact factor: 3.738

3.  Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out.

Authors:  Giuseppe Mulè; Emilio Nardi; Luigi Lattuca; Santina Cottone
Journal:  J Clin Hypertens (Greenwich)       Date:  2018-02-19       Impact factor: 3.738

4.  Prevalence and correlates of chronic kidney disease in a group of patients with hypertension in the Savanah zone of Cameroon: a cross-sectional study in Sub-Saharan Africa.

Authors:  Ba Hamadou; Jérôme Boombhi; Félicité Kamdem; Adeline Fitame; Sylvie Ndongo Amougou; Liliane Kuate Mfeukeu; Chris Nadège Nganou; Alain Menanga; Gloria Ashuntantang
Journal:  Cardiovasc Diagn Ther       Date:  2017-12

5.  Para-perirenal distribution of body fat is associated with reduced glomerular filtration rate regardless of other indices of adiposity in hypertensive patients.

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Review 6.  Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.

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7.  Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study.

Authors:  Stanford E Mwasongwe; Tibor Fülöp; Ronit Katz; Solomon K Musani; Mario Sims; Adolfo Correa; Michael F Flessner; Bessie A Young
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8.  Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension.

Authors:  Sae Young Jae; Kanokwan Bunsawat; Yoon-Ho Choi; Yeon Soo Kim; Rhian M Touyz; Jeong Bae Park; Barry A Franklin
Journal:  J Clin Hypertens (Greenwich)       Date:  2018-02-19       Impact factor: 3.738

9.  Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients.

Authors:  Giulio Geraci; Giuseppe Mulè; Manuela Mogavero; Calogero Geraci; Emilio Nardi; Santina Cottone
Journal:  J Clin Hypertens (Greenwich)       Date:  2016-03-25       Impact factor: 3.738
  9 in total

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