Larisa G Tereshchenko1, Elyar Ghafoori2, Muammar M Kabir2, Markus Kowalsky3. 1. Oregon Health and Science University, Knight Cardiovascular Institute, Portland, OR, USA; Johns Hopkins University School of Medicine, Cardiovascular Division, Baltimore, MD, USA. 2. Oregon Health and Science University, Knight Cardiovascular Institute, Portland, OR, USA. 3. Johns Hopkins University School of Medicine, Cardiovascular Division, Baltimore, MD, USA.
Abstract
AIM: The goal of this study was to compare associations between clinical and ECG predictors of cardiac resynchronization therapy (CRT) response with electrical dyssynchrony. METHODS: Body-surface potentials were recorded using a 120-lead system in 4 patients (age 62 ± 12 y, left ventricular ejection fraction (LVEF) 29 ± 5 %; QRS duration 154 ± 19 ms) with post-myocardial infarction scar and left bundle branch block before CRT implantation. A patient-specific heart-torso model derived from MRI with 291 heart-surface nodes was developed. Electrical dyssynchrony index (EDI) was computed as the standard deviation of activation times on the epicardium while uncoupling index (UI) was measured as the difference between the activation times. RESULTS: QRS duration correlated with mean activation time (r = 0.977; P = 0.023), but did not correlate with EDI or UI. LVEF inversely correlated with activation time at the lowest 20th percentile (r = -0.960; P = 0.040). Sum absolute QRST integral (SAI QRST), measured on orthogonal XYZ ECG, correlated with EDI (r = 0.955; P = 0.045), and characterized late-activated area of the left ventricle. CONCLUSION: SAI QRST is a measure of electrical dyssynchrony on ECG.
AIM: The goal of this study was to compare associations between clinical and ECG predictors of cardiac resynchronization therapy (CRT) response with electrical dyssynchrony. METHODS: Body-surface potentials were recorded using a 120-lead system in 4 patients (age 62 ± 12 y, left ventricular ejection fraction (LVEF) 29 ± 5 %; QRS duration 154 ± 19 ms) with post-myocardial infarction scar and left bundle branch block before CRT implantation. A patient-specific heart-torso model derived from MRI with 291 heart-surface nodes was developed. Electrical dyssynchrony index (EDI) was computed as the standard deviation of activation times on the epicardium while uncoupling index (UI) was measured as the difference between the activation times. RESULTS: QRS duration correlated with mean activation time (r = 0.977; P = 0.023), but did not correlate with EDI or UI. LVEF inversely correlated with activation time at the lowest 20th percentile (r = -0.960; P = 0.040). Sum absolute QRST integral (SAI QRST), measured on orthogonal XYZ ECG, correlated with EDI (r = 0.955; P = 0.045), and characterized late-activated area of the left ventricle. CONCLUSION: SAI QRST is a measure of electrical dyssynchrony on ECG.
Authors: Larisa G Tereshchenko; Alan Cheng; Jason Park; Nicholas Wold; Timothy E Meyer; Michael R Gold; Suneet Mittal; Jagmeet Singh; Kenneth M Stein; Kenneth A Ellenbogen Journal: Heart Rhythm Date: 2015-08-10 Impact factor: 6.343
Authors: Larisa G Tereshchenko; Alan Cheng; Barry J Fetics; Joseph E Marine; David D Spragg; Sunil Sinha; Hugh Calkins; Gordon F Tomaselli; Ronald D Berger Journal: J Electrocardiol Date: 2010-09-15 Impact factor: 1.438
Authors: Michael R Gold; Christophe Thébault; Cecilia Linde; William T Abraham; Bart Gerritse; Stefano Ghio; Martin St John Sutton; Jean-Claude Daubert Journal: Circulation Date: 2012-07-10 Impact factor: 29.690
Authors: Larisa G Tereshchenko; Alan Cheng; Barry J Fetics; Barbara Butcher; Joseph E Marine; David D Spragg; Sunil Sinha; Darshan Dalal; Hugh Calkins; Gordon F Tomaselli; Ronald D Berger Journal: J Electrocardiol Date: 2010-11-20 Impact factor: 1.438
Authors: Sylvain Ploux; Joost Lumens; Zachary Whinnett; Michel Montaudon; Maria Strom; Charu Ramanathan; Nicolas Derval; Adlane Zemmoura; Arnaud Denis; Maxime De Guillebon; Ashok Shah; Mélèze Hocini; Pierre Jaïs; Philippe Ritter; Michel Haïssaguerre; Bruce L Wilkoff; Pierre Bordachar Journal: J Am Coll Cardiol Date: 2013-04-16 Impact factor: 24.094
Authors: Erick A Perez-Alday; Jason A Thomas; Muammar Kabir; Golriz Sedaghat; Nichole Rogovoy; Eelco van Dam; Peter van Dam; William Woodward; Cristina Fuss; Maros Ferencik; Larisa G Tereshchenko Journal: J Electrocardiol Date: 2017-09-01 Impact factor: 1.438
Authors: Jonatan Jacobsson; Rasmus Borgquist; Christian Reitan; Elyar Ghafoori; Neal A Chatterjee; Muammar Kabir; Pyotr G Platonov; Jonas Carlson; Jagmeet P Singh; Larisa G Tereshchenko Journal: Am J Cardiol Date: 2016-05-14 Impact factor: 2.778
Authors: Larisa G Tereshchenko; Nona Sotoodehnia; Colleen M Sitlani; Foram N Ashar; Muammar Kabir; Mary L Biggs; Michael P Morley; Jonathan W Waks; Elsayed Z Soliman; Alfred E Buxton; Tor Biering-Sørensen; Scott D Solomon; Wendy S Post; Thomas P Cappola; David S Siscovick; Dan E Arking Journal: J Am Heart Assoc Date: 2018-04-05 Impact factor: 6.106
Authors: Kazi T Haq; Nichole M Rogovoy; Jason A Thomas; Christopher Hamilton; Katherine J Lutz; Ashley Wirth; Aron B Bender; David M German; Ryle Przybylowicz; Peter van Dam; Thomas A Dewland; Khidir Dalouk; Eric Stecker; Babak Nazer; Peter M Jessel; Karen S MacMurdy; Ignatius Gerardo E Zarraga; Bassel Beitinjaneh; Charles A Henrikson; Merritt Raitt; Cristina Fuss; Maros Ferencik; Larisa G Tereshchenko Journal: Heart Rhythm O2 Date: 2021-06-29