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Literature DB >> 27009959

The Rotavirus Interferon Antagonist NSP1: Many Targets, Many Questions.

Abstract

Rotavirus is a leading cause of death due to diarrhea among young children across the globe. Despite the limited coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding the host innate immune response. Among these strategies is use of the interferon antagonist protein NSP1, which targets cellular proteins required for interferon production to be degraded by the proteasome. Although numerous cellular targets have been described, there remain many questions about the mechanism of NSP1 activity and its role in promoting replication in specific host species.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2016 PMID： 27009959 PMCID： PMC4934742 DOI： 10.1128/JVI.03068-15

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1.

Authors: Joel W Graff; Dana N Mitzel; Carla M Weisend; Michelle L Flenniken; Michele E Hardy
Journal: J Virol Date: 2002-09 Impact factor: 5.103

2. Nondefective rotavirus mutants with an NSP1 gene which has a deletion of 500 nucleotides, including a cysteine-rich zinc finger motif-encoding region (nucleotides 156 to 248), or which has a nonsense codon at nucleotides 153-155.

Authors: K Taniguchi; K Kojima; S Urasawa
Journal: J Virol Date: 1996-06 Impact factor: 5.103

Review 3. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis.

Authors: Jacqueline E Tate; Anthony H Burton; Cynthia Boschi-Pinto; A Duncan Steele; Jazmin Duque; Umesh D Parashar
Journal: Lancet Infect Dis Date: 2011-10-24 Impact factor: 25.071

4. Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains.

Authors: Michelle M Arnold; John T Patton
Journal: J Virol Date: 2010-12-22 Impact factor: 5.103

5. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7.

Authors: Mario Barro; John T Patton
Journal: J Virol Date: 2007-02-14 Impact factor: 5.103

6. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3.

Authors: Mario Barro; John T Patton
Journal: Proc Natl Acad Sci U S A Date: 2005-03-01 Impact factor: 11.205

7. Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

Authors: Rong Zhang; Babal K Jha; Kristen M Ogden; Beihua Dong; Ling Zhao; Ruth Elliott; John T Patton; Robert H Silverman; Susan R Weiss
Journal: Proc Natl Acad Sci U S A Date: 2013-07-22 Impact factor: 11.205

8. IRF3 inhibition by rotavirus NSP1 is host cell and virus strain dependent but independent of NSP1 proteasomal degradation.

Authors: Adrish Sen; Ningguo Feng; Khalil Ettayebi; Michele E Hardy; Harry B Greenberg
Journal: J Virol Date: 2009-08-05 Impact factor: 5.103

9. Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1.

Authors: Ningguo Feng; Linda L Yasukawa; Adrish Sen; Harry B Greenberg
Journal: J Virol Date: 2013-05-22 Impact factor: 5.103

10. Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.

Authors: Marco Morelli; Allison F Dennis; John T Patton
Journal: mBio Date: 2015-01-27 Impact factor: 7.867

14 in total

1. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Authors: Kapil Saxena; Lukas M Simon; Xi-Lei Zeng; Sarah E Blutt; Sue E Crawford; Narayan P Sastri; Umesh C Karandikar; Nadim J Ajami; Nicholas C Zachos; Olga Kovbasnjuk; Mark Donowitz; Margaret E Conner; Chad A Shaw; Mary K Estes
Journal: Proc Natl Acad Sci U S A Date: 2017-01-09 Impact factor: 11.205

2. The Role of the VP4 Attachment Protein in Rotavirus Host Range Restriction in an In Vivo Suckling Mouse Model.

Authors: Liliana Sánchez-Tacuba; Takahiro Kawagishi; Ningguo Feng; Baoming Jiang; Siyuan Ding; Harry B Greenberg
Journal: J Virol Date: 2022-07-12 Impact factor: 6.549

3. Rotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane Protein.

Authors: Julia R Diller; Helen M Parrington; John T Patton; Kristen M Ogden
Journal: J Virol Date: 2019-09-30 Impact factor: 5.103

Review 4. Treading a HOSTile path: Mapping the dynamic landscape of host cell-rotavirus interactions to explore novel host-directed curative dimensions.

Authors: Upayan Patra; Urbi Mukhopadhyay; Arpita Mukherjee; Shanta Dutta; Mamta Chawla-Sarkar
Journal: Virulence Date: 2021-12 Impact factor: 5.882

Review 5. RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses.

Authors: Yuexiu Zhang; Lian-Feng Li; Muhammad Munir; Hua-Ji Qiu
Journal: Front Immunol Date: 2018-05-22 Impact factor: 7.561

6. Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units.

Authors: Upayan Patra; Urbi Mukhopadhyay; Arpita Mukherjee; Rakesh Sarkar; Mamta Chawla-Sarkar
Journal: Oxid Med Cell Longev Date: 2020-04-04 Impact factor: 6.543