| Literature DB >> 27009395 |
Giovanni Stracquadanio1, Xuting Wang2, Marsha D Wallace1, Anna M Grawenda1, Ping Zhang1, Juliet Hewitt1, Jorge Zeron-Medina3, Francesc Castro-Giner4, Ian P Tomlinson4, Colin R Goding1, Kamil J Cygan5,6, William G Fairbrother5,6, Laurent F Thomas7, Pål Sætrom7,8, Federica Gemignani9, Stefano Landi9, Benjamin Schuster-Böckler1, Douglas A Bell2, Gareth L Bond1.
Abstract
Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.Entities:
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Year: 2016 PMID： 27009395 PMCID： PMC6854702 DOI： 10.1038/nrc.2016.15
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716