Literature DB >> 27009339

Hypertension: the missing WNKs.

Hashem A Dbouk1, Chou-Long Huang2, Melanie H Cobb3.   

Abstract

The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.
Copyright © 2016 the American Physiological Society.

Entities:  

Keywords:  WNK; cardiovascular; hypertension

Mesh：

Substances：

Year:  2016        PMID： 27009339      PMCID： PMC4967160          DOI： 10.1152/ajprenal.00358.2015

Source DB:  PubMed          Journal:  Am J Physiol Renal Physiol        ISSN： 1522-1466


  186 in total

Review 1.  Molecular mechanisms of human hypertension.

Authors:  R P Lifton; A G Gharavi; D S Geller
Journal:  Cell       Date:  2001-02-23       Impact factor: 41.582

2.  Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

Authors:  Juliette Hadchouel; Christelle Soukaseum; Cara Büsst; Xiao-ou Zhou; Véronique Baudrie; Tany Zürrer; Michelle Cambillau; Jean-Luc Elghozi; Richard P Lifton; Johannes Loffing; Xavier Jeunemaitre
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205

Review 3.  Familial hyperkalemic hypertension.

Authors:  Juliette Hadchouel; Céline Delaloy; Sébastien Fauré; Jean-Michel Achard; Xavier Jeunemaitre
Journal:  J Am Soc Nephrol       Date:  2005-10-12       Impact factor: 10.121

4.  Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.

Authors:  A-Young Lee; Wei Chen; Steve Stippec; Jon Self; Fan Yang; Xiaojun Ding; She Chen; Yu-Chi Juang; Melanie H Cobb
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-01       Impact factor: 11.205

5.  Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

Authors:  Zhen Y Jiang; Qiong L Zhou; John Holik; Shraddha Patel; John Leszyk; Kerri Coleman; My Chouinard; Michael P Czech
Journal:  J Biol Chem       Date:  2005-03-30       Impact factor: 5.157

6.  Properties of WNK1 and implications for other family members.

Authors:  Lisa Y Lenertz; Byung-Hoon Lee; Xiaoshan Min; Bing-e Xu; Kyle Wedin; Svetlana Earnest; Elizabeth J Goldsmith; Melanie H Cobb
Journal:  J Biol Chem       Date:  2005-05-09       Impact factor: 5.157

7.  Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Authors:  Samarpita Sengupta; Szu-Wei Tu; Kyle Wedin; Svetlana Earnest; Steve Stippec; Katherine Luby-Phelps; Melanie H Cobb
Journal:  J Biol Chem       Date:  2012-09-18       Impact factor: 5.157

8.  Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

Authors:  Jian Xie; Tao Wu; Ke Xu; Ivan K Huang; Ondine Cleaver; Chou-Long Huang
Journal:  Am J Pathol       Date:  2009-07-30       Impact factor: 4.307

9.  Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.

Authors:  Zhengrong Guan; Jennifer S Pollock; Anthony K Cook; Janet L Hobbs; Edward W Inscho
Journal:  Hypertension       Date:  2009-08-31       Impact factor: 10.190

Review 10.  Extrarenal roles of the with-no-lysine[K] kinases (WNKs).

Authors:  Keith Siew; Kevin M O'Shaughnessy
Journal:  Clin Exp Pharmacol Physiol       Date:  2013-12       Impact factor: 2.557
View more
  7 in total

Review 1.  Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.

Authors:  Steven J Forrester; George W Booz; Curt D Sigmund; Thomas M Coffman; Tatsuo Kawai; Victor Rizzo; Rosario Scalia; Satoru Eguchi
Journal:  Physiol Rev       Date:  2018-07-01       Impact factor: 37.312

Review 2.  WNK1 in Malignant Behaviors: A Potential Target for Cancer?

Authors:  Ji-Ung Jung; Ankita B Jaykumar; Melanie H Cobb
Journal:  Front Cell Dev Biol       Date:  2022-06-22

3.  UBR5 is a novel regulator of WNK1 stability.

Authors:  Ji-Ung Jung; Anwesha B Ghosh; Svetlana Earnest; Staci L Deaton; Melanie H Cobb
Journal:  Am J Physiol Cell Physiol       Date:  2022-04-20       Impact factor: 5.282

Review 4.  Emerging Targets of Diuretic Therapy.

Authors:  C-J Cheng; A R Rodan; C-L Huang
Journal:  Clin Pharmacol Ther       Date:  2017-07-10       Impact factor: 6.875

Review 5.  Potassium: friend or foe?

Authors:  Aylin R Rodan
Journal:  Pediatr Nephrol       Date:  2016-05-18       Impact factor: 3.714

6.  WNK3 promotes the invasiveness of glioma cell lines under hypoxia by inducing the epithelial-to-mesenchymal transition.

Authors:  Yue Wang; Bingbing Wu; Shengrong Long; Guangyu Li
Journal:  Transl Neurosci       Date:  2021-08-25       Impact factor: 1.757

7.  Osmosensing by WNK Kinases.

Authors:  Radha Akella; John M Humphreys; Kamil Sekulski; Haixia He; Mateusz Durbacz; Srinivas Chakravarthy; Joanna Liwocha; Zuhair J Mohammed; Chad A Brautigam; Elizabeth J Goldsmith
Journal:  Mol Biol Cell       Date:  2021-03-10       Impact factor: 4.138
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.