Literature DB >> 23027929

Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.

A-Young Lee1, Wei Chen, Steve Stippec, Jon Self, Fan Yang, Xiaojun Ding, She Chen, Yu-Chi Juang, Melanie H Cobb.   

Abstract

We report an action of the protein kinase WNK3 on the neuronal mRNA splicing factor Fox-1. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation. WNK3, implicated in the control of neuronal excitability through actions on ion transport, binds Fox-1 and inhibits its splicing activity in a kinase activity-dependent manner. Phosphorylation of Fox-1 by WNK3 does not change its RNA binding capacity; instead, WNK3 increases the cytoplasmic localization of Fox-1, thereby suppressing Fox-1-dependent splicing. These findings demonstrate a role of WNK3 in RNA processing. Considering the implication of WNK3 and Fox-1 in disorders of neuronal development such as autism, WNK3 may offer a target for treatment of Fox-1-induced disease.

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Year:  2012        PMID： 23027929      PMCID： PMC3479510          DOI： 10.1073/pnas.1215406109

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

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Journal:  Science       Date:  2007-03-15       Impact factor: 47.728

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Journal:  Nucleic Acids Res       Date:  2005-04-11       Impact factor: 16.971
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  5 in total

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Journal:  Stroke       Date:  2015-06-11       Impact factor: 7.914

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5.  Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE.

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  5 in total

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