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Literature DB >> 27008988

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae.

Jiantao Zhang¹, Chaochen Wu², Jiayuan Sheng², Xueyang Feng².

Abstract

We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors. The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.

Entities: Chemical Gene Species

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Year: 2016 PMID： 27008988 DOI： 10.1039/c5mb00888c

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

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Cited

6 in total

Review 1. Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites.

Authors: Miguel Suástegui; Zengyi Shao
Journal: J Ind Microbiol Biotechnol Date: 2016-08-31 Impact factor: 3.346

2. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.

Authors: Javier Murciano-Calles; David K Romney; Sabine Brinkmann-Chen; Andrew R Buller; Frances H Arnold
Journal: Angew Chem Int Ed Engl Date: 2016-08-11 Impact factor: 15.336

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae.

Review 1. Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites.

2. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.

3. Creation of Bacterial cells with 5-Hydroxytryptophan as a 21^st Amino Acid Building Block.

4. Biosynthesis and Genetic Incorporation of 3,4-Dihydroxy-L-Phenylalanine into Proteins in Escherichia coli.

Review 5. Advances in the Microbial Synthesis of 5-Hydroxytryptophan.

6. Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae.

Review 1. Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites.

2. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.

3. Creation of Bacterial cells with 5-Hydroxytryptophan as a 21st Amino Acid Building Block.

4. Biosynthesis and Genetic Incorporation of 3,4-Dihydroxy-L-Phenylalanine into Proteins in Escherichia coli.

Review 5. Advances in the Microbial Synthesis of 5-Hydroxytryptophan.

6. Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.

3. Creation of Bacterial cells with 5-Hydroxytryptophan as a 21^st Amino Acid Building Block.