| Literature DB >> 27008869 |
Maxine M Chen1, Tracy A O'Mara2, Deborah J Thompson3, Jodie N Painter2, John Attia4,5, Amanda Black6, Louise Brinton6, Stephen Chanock6, Chu Chen7, Timothy Ht Cheng8, Linda S Cook9,10, Marta Crous-Bou1,11, Jennifer Doherty12, Christine M Friedenreich13, Montserrat Garcia-Closas6,14, Mia M Gaudet15, Maggie Gorman8, Christopher Haiman16, Susan E Hankinson11,17, Patricia Hartge6, Brian E Henderson16, Shirley Hodgson18, Elizabeth G Holliday4, Pamela L Horn-Ross19, David J Hunter1, Loic Le Marchand20, Xiaolin Liang21, Jolanta Lissowska22, Jirong Long23, Lingeng Lu24, Anthony M Magliocco25, Lynn Martin8, Mark McEvoy5, Sara H Olson21, Irene Orlow21, Loreall Pooler16, Jennifer Prescott11, Radhai Rastogi21, Timothy R Rebbeck26, Harvey Risch24, Carlotta Sacerdote27,28, Frederick Schumacher16, Veronica Wendy Setiawan16, Rodney J Scott4,29,30, Xin Sheng16, Xiao-Ou Shu23, Constance Turman1, David Van Den Berg16, Zhaoming Wang6, Noel S Weiss31, Nicholas Wentzensen6, Lucy Xia16, Yong-Bing Xiang32, Hannah P Yang6, Herbert Yu20, Wei Zheng23, Paul D P Pharoah33, Alison M Dunning33, Ian Tomlinson3, Douglas F Easton3,33, Peter Kraft1, Amanda B Spurdle2, Immaculata De Vivo34,11.
Abstract
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.Entities:
Mesh：
Year: 2016 PMID： 27008869 PMCID： PMC5868213 DOI： 10.1093/hmg/ddw092
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150