Literature DB >> 27002860

Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate.

Kortney M Kersten1, Adam J Matzger.   

Abstract

Structural and thermal data were obtained for a novel hemihydrate of 6-mercaptopurine. The hemihydrate shows increased solubility and bioavailability when compared to the monohydrate form, better stability against conversion in aqueous media than the anhydrate form, and a dehydration temperature of 240 °C, the highest of any known hydrate crystal.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27002860      PMCID： PMC4965881          DOI： 10.1039/c6cc00424e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Trends in solubility of polymorphs.

Authors:  Madhu Pudipeddi; Abu T M Serajuddin
Journal:  J Pharm Sci       Date:  2005-05       Impact factor: 3.534

2.  Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

Authors:  T Dervieux; J G Blanco; E Y Krynetski; E F Vanin; M F Roussel; M V Relling
Journal:  Cancer Res       Date:  2001-08-01       Impact factor: 12.701

3.  Polymorphic and dissolution properties of mercaptopurine.

Authors:  M L Huang; S Niazi
Journal:  J Pharm Sci       Date:  1977-04       Impact factor: 3.534

4.  X-ray structural studies and physicochemical properties of cimetidine polymorphism.

Authors:  M Shibata; H Kokubo; K Morimoto; K Morisaka; T Ishida; M Inoue
Journal:  J Pharm Sci       Date:  1983-12       Impact factor: 3.534

5.  Hydration-induced proton transfer in the solid state of norfloxacin.

Authors:  Ting-Chou Hu; Shun-Li Wang; Ting-Fang Chen; Shan-Yang Lin
Journal:  J Pharm Sci       Date:  2002-05       Impact factor: 3.534

6.  Thermodynamics of mercaptopurine dehydration.

Authors:  S Niazi
Journal:  J Pharm Sci       Date:  1978-04       Impact factor: 3.534

7.  Physical characterization of erythromycin: anhydrate, monohydrate, and dihydrate crystalline solids.

Authors:  P V Allen; P D Rahn; A C Sarapu; A J Vanderwielen
Journal:  J Pharm Sci       Date:  1978-08       Impact factor: 3.534
  7 in total
  4 in total

1.  Mechanisms of Crystal Plasticization by Lattice Water.

Authors:  Chenguang Wang; Changquan Calvin Sun
Journal:  Pharm Res       Date:  2022-03-17       Impact factor: 4.200

2.  Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease.

Authors:  Natasha de Alwis; Bianca R Fato; Sally Beard; Natalie K Binder; Tu'uhevaha J Kaitu'u-Lino; Kenji Onda; Natalie J Hannan
Journal:  Int J Mol Sci       Date:  2022-08-23       Impact factor: 6.208

3.  Survey and analysis of crystal polymorphism in organic structures.

Authors:  Kortney Kersten; Ramanpreet Kaur; Adam Matzger
Journal:  IUCrJ       Date:  2018-01-25       Impact factor: 4.769

4.  A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid.

Authors:  Edvin Brusač; Mario-Livio Jeličić; Matija Cvetnić; Daniela Amidžić Klarić; Biljana Nigović; Ana Mornar
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-17
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.