| Literature DB >> 27002812 |
Emerson M Wickwire1,2, Scott G Williams3,4, Thomas Roth5, Vincent F Capaldi6, Michael Jaffe7,8,9, Margaret Moline10, Gholam K Motamedi11, Gregory W Morgan12, Vincent Mysliwiec4,13, Anne Germain14, Renee M Pazdan15, Reuven Ferziger16, Thomas J Balkin6, Margaret E MacDonald17, Thomas A Macek18, Michael R Yochelson19,20, Steven M Scharf21, Christopher J Lettieri4.
Abstract
Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.Entities:
Keywords: Concussion; Insomnia; Sleep; Sleep apnea; Sleep disorders; Traumatic brain injury
Mesh：
Year: 2016 PMID： 27002812 PMCID： PMC4824019 DOI： 10.1007/s13311-016-0429-3
Source DB: PubMed Journal: Neurotherapeutics ISSN： 1878-7479 Impact factor: 7.620