Adugna Negussie1, Gebru Mulugeta2, Ahmed Bedru3, Ibrahim Ali2, Damte Shimeles4, Tsehaynesh Lema3, Abraham Aseffa3. 1. Department of Medical Laboratory Science, Addis Ababa University, Addis Ababa, Ethiopia; College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia. 2. Department of Medical Laboratory Science, Addis Ababa University, Addis Ababa, Ethiopia. 3. Armauer Hansen Research Institute, Addis Ababa, Ethiopia. 4. Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
Abstract
BACKGROUND: Blood stream infections are major cause of morbidity and mortality in children in developing countries. The emerging of causative agents and resistance to various antimicrobial agents are increased from time to time. The main aim of this study was to determine the bacterial agents and antimicrobial susceptibility patterns among children suspected of having septicemia. METHODS: A cross sectional study involved about 201 pediatric patients (≤ 12 years) was conducted from October 2011 to February 2012 at pediatric units of TikurAnbessa Specialized Hospital and Yekatit 12 Hospital. Standard procedure was followed for blood sample collection, isolate identifications and antimicrobial susceptibility testing. RESULTS: Among 201 study subjects 110 (54.7%) were males. Majority 147 (73.1%) of them were neonates (≤ 28 days). The mean length of hospital stay before sampling was 4.29 days. Out of the 201 tested blood samples, blood cultures were positive in 56 (27.9%).Gram negative and Gram positive bacteria constituted 29(51.8%) and 26(46.4%), respectively. The most frequent pathogen found was Staphylococcus aureus 13 (23.2%), followed by Serratia marcescens 12(21.4%), CoNS 11(19.6%), klebsiella spp 9(16%) and Salmonella spp 3(5.4%). Majority of bacterial isolates showed high resistance to Ampicillin, Penicillin, Co-trimoxazole, Gentamicin and Tetracycline which commonly used in the study area. CONCLUSION: Majority of the isolates were multidrug resistant. These higher percentages of multi-drug resistant emerged isolates urge us to take infection prevention measures and to conduct other large studies for appropriate empiric antibiotic choice.
BACKGROUND: Blood stream infections are major cause of morbidity and mortality in children in developing countries. The emerging of causative agents and resistance to various antimicrobial agents are increased from time to time. The main aim of this study was to determine the bacterial agents and antimicrobial susceptibility patterns among children suspected of having septicemia. METHODS: A cross sectional study involved about 201 pediatric patients (≤ 12 years) was conducted from October 2011 to February 2012 at pediatric units of TikurAnbessa Specialized Hospital and Yekatit 12 Hospital. Standard procedure was followed for blood sample collection, isolate identifications and antimicrobial susceptibility testing. RESULTS: Among 201 study subjects 110 (54.7%) were males. Majority 147 (73.1%) of them were neonates (≤ 28 days). The mean length of hospital stay before sampling was 4.29 days. Out of the 201 tested blood samples, blood cultures were positive in 56 (27.9%).Gram negative and Gram positive bacteria constituted 29(51.8%) and 26(46.4%), respectively. The most frequent pathogen found was Staphylococcus aureus 13 (23.2%), followed by Serratia marcescens 12(21.4%), CoNS 11(19.6%), klebsiella spp 9(16%) and Salmonella spp 3(5.4%). Majority of bacterial isolates showed high resistance to Ampicillin, Penicillin, Co-trimoxazole, Gentamicin and Tetracycline which commonly used in the study area. CONCLUSION: Majority of the isolates were multidrug resistant. These higher percentages of multi-drug resistant emerged isolates urge us to take infection prevention measures and to conduct other large studies for appropriate empiric antibiotic choice.
Authors: L K Archibald; L C McDonald; O Nwanyanwu; P Kazembe; H Dobbie; J Tokars; L B Reller; W R Jarvis Journal: J Infect Dis Date: 2000-04-13 Impact factor: 5.226
Authors: Seyed Mehdi Sajjadi; Ali Akbar Pourfathollah; Saeed Mohammadi; Bijan Nouri; Rostam Hassanzadeh; Fariba Rad Journal: Iran J Public Health Date: 2018-07 Impact factor: 1.429