Hirotoshi Ishiwatari1, Tsuyoshi Hayashi1, Hiroshi Kawakami2, Hiroyuki Isayama3, Hiroyuki Hisai4, Takao Itoi5, Michihiro Ono1, Kazumichi Kawakubo2, Natsuyo Yamamoto3, Mariko Tanaka6, Fumihide Itokawa5, Hisashi Oshiro7, Tomoko Sonoda8, Tadashi Hasegawa9. 1. Department of Medical Oncology and Hematology, Sapporo Medical University, Sapporo, Japan. 2. Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan. 3. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 4. Department of Gastroenterology, Japanese Red Cross Date General Hospital, Hokkaido, Japan. 5. Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. 6. Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 7. Department of Pathology, Tokyo Medical University, Tokyo, Japan. 8. Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan. 9. Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Abstract
BACKGROUND AND AIMS: A side-port needle has been developed to improve diagnostic accuracy by obtaining more cellular material during EUS-guided FNA (EUS-FNA). We compared the accuracy rate of histology and the quality of histologic specimens from 22-gauge (G) side-port and standard needles for EUS-FNA of a solid pancreatic mass in a multicenter, prospective, randomized control trial. METHODS:Between January 2013 and September 2013, 160 consecutive patients with a suspected solid pancreatic mass at 5 tertiary referral centers were enrolled. Patients were randomized to the 22G side-port needle or 22G standard needle group. The primary endpoint was the diagnostic accuracy of histology. Secondary endpoints were the quality of the histologic specimen (quantity of tissue, degree of GI contamination, and amount of blood). RESULTS: An analysis of 154 patients (side-port, 76, vs standard, 78) was performed. Six patients were excluded because of no pancreatic mass on EUS. There was no significant difference in the rate of diagnostic accuracy of histology (side-port, 87% [66/76], vs standard, 82% [64/78]; P = .51). Samples that enabled histologic interpretation were obtained in 64% (47/73) and 43% (33/77) of patients from the side-port and standard groups, respectively (P = .009). No significant difference was seen in the degree of GI contamination and amount of blood between groups. CONCLUSIONS: There was no significant difference in the accuracy rate of histology between needle types. The side-port needle was superior to the standard needle in terms of obtaining samples that enabled histologic interpretation.
RCT Entities:
BACKGROUND AND AIMS: A side-port needle has been developed to improve diagnostic accuracy by obtaining more cellular material during EUS-guided FNA (EUS-FNA). We compared the accuracy rate of histology and the quality of histologic specimens from 22-gauge (G) side-port and standard needles for EUS-FNA of a solid pancreatic mass in a multicenter, prospective, randomized control trial. METHODS: Between January 2013 and September 2013, 160 consecutive patients with a suspected solid pancreatic mass at 5 tertiary referral centers were enrolled. Patients were randomized to the 22G side-port needle or 22G standard needle group. The primary endpoint was the diagnostic accuracy of histology. Secondary endpoints were the quality of the histologic specimen (quantity of tissue, degree of GI contamination, and amount of blood). RESULTS: An analysis of 154 patients (side-port, 76, vs standard, 78) was performed. Six patients were excluded because of no pancreatic mass on EUS. There was no significant difference in the rate of diagnostic accuracy of histology (side-port, 87% [66/76], vs standard, 82% [64/78]; P = .51). Samples that enabled histologic interpretation were obtained in 64% (47/73) and 43% (33/77) of patients from the side-port and standard groups, respectively (P = .009). No significant difference was seen in the degree of GI contamination and amount of blood between groups. CONCLUSIONS: There was no significant difference in the accuracy rate of histology between needle types. The side-port needle was superior to the standard needle in terms of obtaining samples that enabled histologic interpretation.
Authors: Elia Armellini; Erminia Manfrin; Elena Trisolini; Silvano Andorno; Marco Ballarè; Laura Bernardoni; Renzo Luciano Boldorini; Armando Gabbrielli; Luca Frulloni; Alberto Larghi; Pietro Occhipinti; Aldo Scarpa; Stefano Francesco Crinò Journal: United European Gastroenterol J Date: 2018-09-30 Impact factor: 4.623
Authors: Samuel Han; Furqan Bhullar; Omar Alaber; Ayesha Kamal; Puanani Hopson; Kavin Kanthasamy; Sarah Coughlin; Livia Archibugi; Nikhil Thiruvengadam; Christopher Moreau; David Jin; Pedram Paragomi; Francisco Valverde-López; Sajan Nagpal; Cemal Yazici; Georgios Papchristou; Peter J Lee; Venkata Akshintala Journal: Endosc Int Open Date: 2021-05-27