Matthias Benndorf1, Yirong Wu2, Elizabeth S Burnside3. 1. University Hospital Freiburg, Department of Radiology, Hugstetter Straße 55, 79106 Freiburg, Germany. Electronic address: matthias.benndorf@uniklinik-freiburg.de. 2. Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: ywu@uwhealth.org. 3. Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: eburnside@uwhealth.org.
Abstract
OBJECTIVE: The objective was to investigate whether risk stratification of mammographic Breast Imaging: Reporting and Data System (BI-RADS) 3 can be accomplished in the diagnostic setting. METHODS: We analyzed 4941 BI-RADS-3-rated patients (23 malignant outcomes) and built logistic-regression models with age, personal and family history of breast cancer, fibroglandular density, and additional mammographic findings as predictive variables. RESULTS: A personal history of breast cancer (odds ratio: 5.53) and older age (odds ratio: 12.44/10.93 for age 50-64/>64) are independent risk factors. Patients with both risk factors have a risk >2%. CONCLUSION: Biopsy may be warranted in older patients with a history of breast cancer who would be otherwise assigned BI-RADS 3.
OBJECTIVE: The objective was to investigate whether risk stratification of mammographic Breast Imaging: Reporting and Data System (BI-RADS) 3 can be accomplished in the diagnostic setting. METHODS: We analyzed 4941 BI-RADS-3-rated patients (23 malignant outcomes) and built logistic-regression models with age, personal and family history of breast cancer, fibroglandular density, and additional mammographic findings as predictive variables. RESULTS: A personal history of breast cancer (odds ratio: 5.53) and older age (odds ratio: 12.44/10.93 for age 50-64/>64) are independent risk factors. Patients with both risk factors have a risk >2%. CONCLUSION: Biopsy may be warranted in older patients with a history of breast cancer who would be otherwise assigned BI-RADS 3.
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