Huda Jawad1, Duncan S Bain2, Helen Dawson3, Kate Crawford3, Atholl Johnston2, Arthur Tucker4. 1. Department of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. Electronic address: hjawad@uob.edu.bh. 2. Department of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. 3. Ernest Cooke Vascular & Microvascular Unit, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom. 4. Department of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom; Ernest Cooke Vascular & Microvascular Unit, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
Abstract
OBJECTIVE: This study compares the effectiveness of a neuromuscular electrostimulation device (geko T-1; Firstkind Ltd, High Wycombe, UK) in enhancing lower limb blood perfusion with two leading intermittent pneumatic compression (IPC) devices, the Huntleigh Flowtron Universal (Huntleigh Healthcare Ltd, Cardiff, UK) and the Kendall SCD Express (Covidien plc, Dublin, Ireland). The subjects' tolerance of the devices was also compared. METHODS: Ten healthy subjects were recruited. The devices were fitted bilaterally, in a sequential manner, for 30 minutes. Ultrasound and laser Doppler fluxmetry assessments were performed. RESULTS: The geko T-1 device was superior to both IPC devices in increasing both venous and arterial blood volume flow by ∼30% (95% confidence interval [CI], 23.7%-82.4%; P ≤ .001). The geko T-1 increased arterial blood velocity by 24% (95% CI, 9.7%-24.5%; P ≤ .001). A substantial increase in the total microcirculatory blood velocity by ∼370% (95% CI, 13.5%-39.7%) was reported after the use of the geko T-1 (P ≤ .001). With use of the visual analog scale, no significant differences in discomfort were found between the geko T-1 device and the IPC devices (P >.05). CONCLUSIONS: The geko T-1 device is more effective than the IPC devices in increasing venous, arterial, and microcirculatory blood velocity. The devices studied were safe and well tolerated by healthy subjects.
OBJECTIVE: This study compares the effectiveness of a neuromuscular electrostimulation device (geko T-1; Firstkind Ltd, High Wycombe, UK) in enhancing lower limb blood perfusion with two leading intermittent pneumatic compression (IPC) devices, the Huntleigh Flowtron Universal (Huntleigh Healthcare Ltd, Cardiff, UK) and the Kendall SCD Express (Covidien plc, Dublin, Ireland). The subjects' tolerance of the devices was also compared. METHODS: Ten healthy subjects were recruited. The devices were fitted bilaterally, in a sequential manner, for 30 minutes. Ultrasound and laser Doppler fluxmetry assessments were performed. RESULTS: The geko T-1 device was superior to both IPC devices in increasing both venous and arterial blood volume flow by ∼30% (95% confidence interval [CI], 23.7%-82.4%; P ≤ .001). The geko T-1 increased arterial blood velocity by 24% (95% CI, 9.7%-24.5%; P ≤ .001). A substantial increase in the total microcirculatory blood velocity by ∼370% (95% CI, 13.5%-39.7%) was reported after the use of the geko T-1 (P ≤ .001). With use of the visual analog scale, no significant differences in discomfort were found between the geko T-1 device and the IPC devices (P >.05). CONCLUSIONS: The geko T-1 device is more effective than the IPC devices in increasing venous, arterial, and microcirculatory blood velocity. The devices studied were safe and well tolerated by healthy subjects.
Authors: Christopher R Lattimer; Vassilios Zymvragoudakis; George Geroulakos; Evi Kalodiki Journal: Clin Appl Thromb Hemost Date: 2017-09-06 Impact factor: 2.389
Authors: Elisa Benito-Martínez; Diego Senovilla-Herguedas; Julio César de la Torre-Montero; María Jesús Martínez-Beltrán; María Mercedes Reguera-García; Beatriz Alonso-Cortés Journal: Int J Environ Res Public Health Date: 2020-12-03 Impact factor: 3.390