Ring opening of aziridinium ions with nitrogen nucleophiles was applied to the highly efficient synthesis of optically active vicinal diamines and diethylene triamine pentaacetic acid (DTPA) analogues as potential magnetic resonance imaging (MRI) contrast enhancement agents. The synthetic method features a column-free isolation of the regiospecific and stereospecific nucleophilic substitution products of enantiomerically enriched aziridinium ions in excellent yield.
Ring opening of aziridinium ions with n class="Chemical">nitrogen nucleophiles was applied to the highly efficient synthesis of optically active vicinal diamines and diethylene triamine pentaacetic acid (DTPA) analogues as potential magnetic resonance imaging (MRI) contrast enhancement agents. The synthetic method features a column-free isolation of the regiospecific and stereospecific nucleophilic substitution products of enantiomerically enriched aziridinium ions in excellent yield.
Authors: Anouk Dirksen; Sander Langereis; Bas F M de Waal; Marcel H P van Genderen; E W Meijer; Quido G de Lussanet; Tilman M Hackeng Journal: Org Lett Date: 2004-12-23 Impact factor: 6.005
Authors: Heng Xu; Celeste A S Regino; Marcelino Bernardo; Yoshinori Koyama; Hisataka Kobayashi; Peter L Choyke; Martin W Brechbiel Journal: J Med Chem Date: 2007-06-07 Impact factor: 7.446