C J Poston1, T C Pierce1, Y Li2, C W Brinson2, Z Lu3, A W Lauer4, R S Leite1, Y Huang2,3. 1. Division of Periodontics, Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA. 2. Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA. 3. Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA. 4. Division of Biostatistics, Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Abstract
BACKGROUND: This study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non-diabetic and diabetic patients. METHODS: We first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 non-diabetic and diabetic patients, who all had periodontitis and took or did not take statin, and measured periodontal probing depth (PPD) and clinical attachment level (CAL), and collected gingival crevicular fluid (GCF) to quantify MMPs. RESULTS: The in vitro studies showed that simvastatin potently inhibited the expression of MMP-1, MMP-8, and MMP-9 upregulated by lipopolysaccharide (LPS) and high glucose in mononuclear cells. The patient study showed that, after adjusting for age and smoking status, PPD in diabetic patients on statin was significantly less than that in diabetic patients not on statin. MMP-1 level in GCF of non-diabetic and diabetic patients on statin was lower than that of non-diabetic and diabetic patients not on statin, respectively. No difference was found for MMP-8 and -9 levels in GCF. CONCLUSION: Statin intake is associated with reduced PPD in diabetic patients and MMP-1 level in GCF in either non-diabetic or diabetic patients. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
BACKGROUND: This study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non-diabetic and diabeticpatients. METHODS: We first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 non-diabetic and diabeticpatients, who all had periodontitis and took or did not take statin, and measured periodontal probing depth (PPD) and clinical attachment level (CAL), and collected gingival crevicular fluid (GCF) to quantify MMPs. RESULTS: The in vitro studies showed that simvastatin potently inhibited the expression of MMP-1, MMP-8, and MMP-9 upregulated by lipopolysaccharide (LPS) and high glucose in mononuclear cells. The patient study showed that, after adjusting for age and smoking status, PPD in diabeticpatients on statin was significantly less than that in diabeticpatients not on statin. MMP-1 level in GCF of non-diabetic and diabeticpatients on statin was lower than that of non-diabetic and diabeticpatients not on statin, respectively. No difference was found for MMP-8 and -9 levels in GCF. CONCLUSION:Statin intake is associated with reduced PPD in diabeticpatients and MMP-1 level in GCF in either non-diabetic or diabeticpatients. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
Authors: J Jin; X Zhang; Z Lu; Y Li; M F Lopes-Virella; H Yu; C J Haycraft; Q Li; K L Kirkwood; Y Huang Journal: J Periodontal Res Date: 2013-10-07 Impact factor: 4.419
Authors: Kamala P Sundararaj; Devadoss J Samuvel; Yanchun Li; Alena Nareika; Elizabeth H Slate; John J Sanders; Maria F Lopes-Virella; Yan Huang Journal: J Leukoc Biol Date: 2008-07-14 Impact factor: 4.962
Authors: Jonathan Meza-Mauricio; David Soto-Peñaloza; David Peñarrocha-Oltra; Jose Maria Montiel-Company; Daiane Cristina Peruzzo Journal: Clin Oral Investig Date: 2018-06-12 Impact factor: 3.573
Authors: Mariano Sanz; Alvaro Marco Del Castillo; Søren Jepsen; Jose R Gonzalez-Juanatey; Francesco D'Aiuto; Philippe Bouchard; Iain Chapple; Thomas Dietrich; Israel Gotsman; Filippo Graziani; David Herrera; Bruno Loos; Phoebus Madianos; Jean-Baptiste Michel; Pablo Perel; Burkert Pieske; Lior Shapira; Michael Shechter; Maurizio Tonetti; Charalambos Vlachopoulos; Gernot Wimmer Journal: J Clin Periodontol Date: 2020-02-03 Impact factor: 8.728
Authors: M Sanz; A Marco Del Castillo; S Jepsen; J R Gonzalez-Juanatey; F D'Aiuto; P Bouchard; I Chapple; T Dietrich; I Gotsman; F Graziani; D Herrera; B Loos; P Madianos; J B Michel; P Perel; B Pieske; L Shapira; M Shechter; M Tonetti; C Vlachopoulos; G Wimmer Journal: Glob Heart Date: 2020-02-03