Neil Bhardwaj1, Ashley R Dennison2, Guy J Maddern3, Giuseppe Garcea2. 1. University Hospitals Leicester, Department of HPB Surgery, Leicester, LE5 4PW, UK. Electronic address: neilbhardwaj@yahoo.co.uk. 2. University Hospitals Leicester, Department of HPB Surgery, Leicester, LE5 4PW, UK. 3. University of Adelaide, Discipline of Surgery, The Queen Elizabeth Hospital, Woodville, Adelaide, Australia.
Abstract
INTRODUCTION: IPMN is a relatively new clinical entity and surgeons are continuing to develop their understanding of this complex pathology. Little is known of the natural disease process post-resection of an IPMN, particularly the impact of gland histology and margin status on the chance of recurrence and survival in benign and invasive IPMN. METHODS: An online search was conducted to evaluate and include those studies which reported on gland histology, margin status and disease recurrence in resected benign and malignant IPMN. A Meta analysis was then performed using a random effects model. RESULTS: The chance of recurrence in non-invasive margin positive IPMN is similar to margin negative IPMN. The chance of recurrence is higher in invasive gland IPMN compared to non-invasive gland. The vast majority of recurrences occurred in patients with positive margins demonstrating invasion. CONCLUSION: All patients with intra- or post-operative evidence of invasive carcinoma at the resection margin should undergo further resection to achieve a negative margin. Patients with evidence of IPMN at the transaction margin (even with changes of high grade dysplasia/CIS) may not achieve any benefit from further resection. Patients with recurrence in benign/non-invasive IPMN should undergo re-resection, whereas patients with recurrence in invasive IPMN should not.
INTRODUCTION: IPMN is a relatively new clinical entity and surgeons are continuing to develop their understanding of this complex pathology. Little is known of the natural disease process post-resection of an IPMN, particularly the impact of gland histology and margin status on the chance of recurrence and survival in benign and invasive IPMN. METHODS: An online search was conducted to evaluate and include those studies which reported on gland histology, margin status and disease recurrence in resected benign and malignant IPMN. A Meta analysis was then performed using a random effects model. RESULTS: The chance of recurrence in non-invasive margin positive IPMN is similar to margin negative IPMN. The chance of recurrence is higher in invasive gland IPMN compared to non-invasive gland. The vast majority of recurrences occurred in patients with positive margins demonstrating invasion. CONCLUSION: All patients with intra- or post-operative evidence of invasive carcinoma at the resection margin should undergo further resection to achieve a negative margin. Patients with evidence of IPMN at the transaction margin (even with changes of high grade dysplasia/CIS) may not achieve any benefit from further resection. Patients with recurrence in benign/non-invasive IPMN should undergo re-resection, whereas patients with recurrence in invasive IPMN should not.
Authors: Mohammad Al Efishat; Marc A Attiyeh; Anne A Eaton; Mithat Gönen; Olca Basturk; David Klimstra; Michael I D'Angelica; Ronald P DeMatteo; T Peter Kingham; Vinod Balachandran; William R Jarnagin; Peter J Allen Journal: Ann Surg Oncol Date: 2018-03-27 Impact factor: 5.344