Literature DB >> 26987591

Introduction to metabolomics and its applications in ophthalmology.

S Z Tan1,2, P Begley3,4, G Mullard3,4, K A Hollywood3,4,5, P N Bishop1,2,4.   

Abstract

Metabolomics is the study of endogenous and exogenous metabolites in biological systems, which aims to provide comparative semi-quantitative information about all metabolites in the system. Metabolomics is an emerging and potentially powerful tool in ophthalmology research. It is therefore important for health professionals and researchers involved in the speciality to understand the basic principles of metabolomics experiments. This article provides an overview of the experimental workflow and examples of its use in ophthalmology research from the study of disease metabolism and pathogenesis to identification of biomarkers.

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Year:  2016        PMID： 26987591      PMCID： PMC4906451          DOI： 10.1038/eye.2016.37

Source DB:  PubMed          Journal:  Eye (Lond)        ISSN： 0950-222X            Impact factor:   3.775


  70 in total

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Authors:  Warwick B Dunn; David I Broadhurst; Helen J Atherton; Royston Goodacre; Julian L Griffin
Journal:  Chem Soc Rev       Date:  2010-08-17       Impact factor: 54.564

Review 2.  Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes.

Authors:  Warwick B Dunn
Journal:  Phys Biol       Date:  2008-02-20       Impact factor: 2.583

3.  Ascorbic acid content of human corneal epithelium.

Authors:  R F Brubaker; W M Bourne; L A Bachman; J W McLaren
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-06       Impact factor: 4.799

4.  Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy.

Authors:  Robert A Honkanen; Sankar Baruah; M Bridget Zimmerman; Cheryl L Khanna; Yaffa K Weaver; Joanna Narkiewicz; Rafiq Waziri; Karen M Gehrs; Thomas A Weingeist; H Culver Boldt; James C Folk; Stephen R Russell; Young H Kwon
Journal:  Arch Ophthalmol       Date:  2003-02

5.  Metabolomic composition of normal aged and cataractous human lenses.

Authors:  Yuri P Tsentalovich; Timofey D Verkhovod; Vadim V Yanshole; Alexey S Kiryutin; Lyudmila V Yanshole; Anjella Zh Fursova; Denis A Stepakov; Vladimir P Novoselov; Renad Z Sagdeev
Journal:  Exp Eye Res       Date:  2015-03-12       Impact factor: 3.467

6.  Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis.

Authors:  Min Li; Hui Li; Peng Jiang; Xiaoqiang Liu; Ding Xu; Fang Wang
Journal:  Mol Biosyst       Date:  2014-05

7.  Glycolytic activity in the human cornea monitored with nuclear magnetic resonance spectroscopy.

Authors:  J D Gottsch; C H Chen; J B Aguayo; J P Cousins; E R Strahlman; W J Stark
Journal:  Arch Ophthalmol       Date:  1986-06

8.  Vitreal glutamate concentration in monkeys with experimental glaucoma.

Authors:  Louvenia Carter-Dawson; Morris L J Crawford; Ronald S Harwerth; Earl L Smith; Robert Feldman; F Fran Shen; Cheryl K Mitchell; Amy Whitetree
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-08       Impact factor: 4.799

9.  Metabolic status of fresh v eye-bank-processed corneas. A phosphorus nuclear magnetic resonance study.

Authors:  J V Greiner; J H Lass; T Glonek
Journal:  Arch Ophthalmol       Date:  1984-11

10.  Metabolome-wide association study of neovascular age-related macular degeneration.

Authors:  Melissa P Osborn; Youngja Park; Megan B Parks; L Goodwin Burgess; Karan Uppal; Kichun Lee; Dean P Jones; Milam A Brantley
Journal:  PLoS One       Date:  2013-08-27       Impact factor: 3.240
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  22 in total

1.  Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers.

Authors:  Inês Laíns; Rachel S Kelly; John B Miller; Rufino Silva; Demetrios G Vavvas; Ivana K Kim; Joaquim N Murta; Jessica Lasky-Su; Joan W Miller; Deeba Husain
Journal:  Ophthalmology       Date:  2017-09-12       Impact factor: 12.079

2.  Metabolomics in Exercise and Sports: A Systematic Review.

Authors:  Kayvan Khoramipour; Øyvind Sandbakk; Ammar Hassanzadeh Keshteli; Abbas Ali Gaeini; David S Wishart; Karim Chamari
Journal:  Sports Med       Date:  2021-10-30       Impact factor: 11.136

Review 3.  Metabolomics for exposure assessment and toxicity effects of occupational pollutants: current status and future perspectives.

Authors:  Fatemeh Dehghani; Saeed Yousefinejad; Douglas I Walker; Fariborz Omidi
Journal:  Metabolomics       Date:  2022-09-09       Impact factor: 4.747

4.  Pharmacokinetic-Pharmacometabolomic Approach in Early-Phase Clinical Trials: A Way Forward for Targeted Therapy in Type 2 Diabetes.

Authors:  Khim Boon Tee; Luqman Ibrahim; Najihah Mohd Hashim; Mohd Zuwairi Saiman; Zaril Harza Zakaria; Hasniza Zaman Huri
Journal:  Pharmaceutics       Date:  2022-06-15       Impact factor: 6.525

5.  Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration.

Authors:  Yanhui Deng; Ping Shuai; Haixin Wang; Shanshan Zhang; Jie Li; Mingyan Du; Peirong Huang; Chao Qu; Lulin Huang
Journal:  Aging (Albany NY)       Date:  2021-05-04       Impact factor: 5.682

6.  Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.

Authors:  Hiroshi Kunikata; Tomoaki Ida; Kota Sato; Naoko Aizawa; Tomohiro Sawa; Hiroshi Tawarayama; Namie Murayama; Shigemoto Fujii; Takaaki Akaike; Toru Nakazawa
Journal:  Sci Rep       Date:  2017-02-07       Impact factor: 4.379

7.  Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways.

Authors:  Zhi Zheng; Liting Xu; Shuofeng Zhang; Wuping Li; Fangfang Tou; Qinsi He; Jun Rao; Qiang Shen
Journal:  Oncotarget       Date:  2017-07-18

8.  Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs.

Authors:  Jinglei Yang; Peter S Reinach; Sen Zhang; Miaozhen Pan; Wenfeng Sun; Bo Liu; Fen Li; Xiaoqing Li; Aihua Zhao; Tianlu Chen; Wei Jia; Jia Qu; Xiangtian Zhou
Journal:  Sci Rep       Date:  2017-06-05       Impact factor: 4.379

9.  Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics.

Authors:  Juan Manuel Chao de la Barca; Nuan-Ting Huang; Haihan Jiao; Lydie Tessier; Cédric Gadras; Gilles Simard; Riccardo Natoli; Guillaume Tcherkez; Pascal Reynier; Krisztina Valter
Journal:  Metabolomics       Date:  2017-01-20       Impact factor: 4.290

10.  Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration.

Authors:  Inês Laíns; Daniela Duarte; António S Barros; Ana Sofia Martins; Tatiana J Carneiro; João Q Gil; John B Miller; Marco Marques; Tânia S Mesquita; Patrícia Barreto; Ivana K Kim; Maria da Luz Cachulo; Demetrios G Vavvas; Isabel M Carreira; Joaquim Neto Murta; Rufino Silva; Joan W Miller; Deeba Husain; Ana M Gil
Journal:  J Proteome Res       Date:  2019-02-06       Impact factor: 4.466
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