Yong-Il Kim1, Jin Chul Paeng2, Gi Jeong Cheon3, Kyung-Suk Suh4, Dong Soo Lee5, June-Key Chung3, Keon Wook Kang3. 1. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea; and. 2. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea paengjc@snu.ac.kr. 3. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 4. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. 5. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea; and.
Abstract
UNLABELLED: (18)F-FDG PET is an effective method of predicting recurrence of hepatocellular carcinoma (HCC) after liver transplantation. We compared recently introduced metabolic and volumetric (18)F-FDG PET/CT indices with the current clinicopathologic predictors for ability to predict recurrence. METHODS: In total, 110 HCC patients who underwent (18)F-FDG PET and liver transplantation were enrolled. On PET, SUVs and tumor-to-background ratios (TBRs) were measured as metabolic activity indices. Various metabolic tumor volumes and uptake-volume products (UVP) were also measured as volumetric indices. The ability of these indices and other clinicopathologic factors to predict recurrence was compared. RESULTS: All metabolic and volumetric indices were significant for recurrence prediction on receiver-operating-characteristic curve analyses (P < 0.001). On univariate survival analyses, all PET indices-as well as tumor size, tumor number, the Milan criteria, tumor grade, vascular invasion, and T-stage-were significant factors. However, on multivariate analyses, tumor size, tumor grade, maximum TBR, and UVP calculated by inferior vena cava activity were significant factors (P = 0.004, 0.014, 0.009, and 0.021, respectively). When the Milan criteria and PET factors were included in the multivariate analysis, the Milan criteria (P = 0.029), maximum TBR (P < 0.001), and UVP (P = 0.016) were significant. CONCLUSION: Volumetric and metabolic activity indices of (18)F-FDG PET are effective predictors of posttransplantation HCC recurrence. In addition to clinicopathologic factors, these indices need to be considered in the selection of candidates for liver transplantation.
UNLABELLED: (18)F-FDG PET is an effective method of predicting recurrence of hepatocellular carcinoma (HCC) after liver transplantation. We compared recently introduced metabolic and volumetric (18)F-FDG PET/CT indices with the current clinicopathologic predictors for ability to predict recurrence. METHODS: In total, 110 HCC patients who underwent (18)F-FDG PET and liver transplantation were enrolled. On PET, SUVs and tumor-to-background ratios (TBRs) were measured as metabolic activity indices. Various metabolic tumor volumes and uptake-volume products (UVP) were also measured as volumetric indices. The ability of these indices and other clinicopathologic factors to predict recurrence was compared. RESULTS: All metabolic and volumetric indices were significant for recurrence prediction on receiver-operating-characteristic curve analyses (P < 0.001). On univariate survival analyses, all PET indices-as well as tumor size, tumor number, the Milan criteria, tumor grade, vascular invasion, and T-stage-were significant factors. However, on multivariate analyses, tumor size, tumor grade, maximum TBR, and UVP calculated by inferior vena cava activity were significant factors (P = 0.004, 0.014, 0.009, and 0.021, respectively). When the Milan criteria and PET factors were included in the multivariate analysis, the Milan criteria (P = 0.029), maximum TBR (P < 0.001), and UVP (P = 0.016) were significant. CONCLUSION: Volumetric and metabolic activity indices of (18)F-FDG PET are effective predictors of posttransplantation HCC recurrence. In addition to clinicopathologic factors, these indices need to be considered in the selection of candidates for liver transplantation.
Authors: Yazan Abuodeh; Arash O Naghavi; Kamran A Ahmed; Puja S Venkat; Youngchul Kim; Bela Kis; Junsung Choi; Benjamin Biebel; Jennifer Sweeney; Daniel A Anaya; Richard Kim; Mokenge Malafa; Jessica M Frakes; Sarah E Hoffe; Ghassan El-Haddad Journal: World J Gastroenterol Date: 2016-12-21 Impact factor: 5.742
Authors: Yong-Il Kim; Gi Jeong Cheon; Seo Young Kang; Jin Chul Paeng; Keon Wook Kang; Dong Soo Lee; June-Key Chung Journal: EJNMMI Res Date: 2018-01-10 Impact factor: 3.138
Authors: Paul Blanc-Durand; Axel Van Der Gucht; Adrien Depeursinge; Niklaus Schaefer; Mario Jreige; Marie Nicod-Lalonde; Marina Silva-Monteiro; John O Prior; Alban Denys Journal: Oncotarget Date: 2017-12-19