Literature DB >> 26984851

Human Circulating T Follicular Helper Cell Subsets in Health and Disease.

Hideki Ueno1.   

Abstract

T follicular helper (Tfh) cells are specialized to provide help to B cells and to induce durable antibody response. Our knowledge on the biology of Tfh cells and their contribution to disease has significantly increased in the past decade. In particular, recent discoveries of functionally distinct subsets within circulating Tfh (cTfh) cells in human blood have provided clues to assess the ongoing Tfh responses in healthy subjects after vaccinations and in patients with autoimmune diseases. The immune pathways associated with Tfh cell differentiation in humans are also getting revealed. In this review, I will first summarize the subsets within human cTfh cells, and discuss their alterations in patients with autoimmune diseases. Then I will discuss the mechanisms associated with the aberrant Tfh responses in human autoimmune diseases.

Entities:  

Keywords:  T follicular helper cells; autoimmune diseases; ctfh cells; humans; subsets; t cell differentiation

Mesh：

Substances：

Year:  2016        PMID： 26984851     DOI： 10.1007/s10875-016-0268-3

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  51 in total

1.  ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.

Authors:  Youn Soo Choi; Robin Kageyama; Danelle Eto; Tania C Escobar; Robert J Johnston; Laurel Monticelli; Christopher Lao; Shane Crotty
Journal:  Immunity       Date:  2011-06-24       Impact factor: 31.745

2.  Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Authors:  Cindy S Ma; Danielle T Avery; Anna Chan; Marcel Batten; Jacinta Bustamante; Stephanie Boisson-Dupuis; Peter D Arkwright; Alexandra Y Kreins; Diana Averbuch; Dan Engelhard; Klaus Magdorf; Sara S Kilic; Yoshiyuki Minegishi; Shigeaki Nonoyama; Martyn A French; Sharon Choo; Joanne M Smart; Jane Peake; Melanie Wong; Paul Gray; Matthew C Cook; David A Fulcher; Jean-Laurent Casanova; Elissa K Deenick; Stuart G Tangye
Journal:  Blood       Date:  2012-03-08       Impact factor: 22.113

Review 3.  The good, the bad and the ugly - TFH cells in human health and disease.

Authors:  Stuart G Tangye; Cindy S Ma; Robert Brink; Elissa K Deenick
Journal:  Nat Rev Immunol       Date:  2013-05-17       Impact factor: 53.106

4.  Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.

Authors:  Lino L Teichmann; Jaime L Cullen; Michael Kashgarian; Chen Dong; Joe Craft; Mark J Shlomchik
Journal:  Immunity       Date:  2015-03-17       Impact factor: 31.745

Review 5.  Germinal centers.

Authors:  I C MacLennan
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

6.  OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.

Authors:  Clément Jacquemin; Nathalie Schmitt; Cécile Contin-Bordes; Yang Liu; Priya Narayanan; Julien Seneschal; Typhanie Maurouard; David Dougall; Emily Spence Davizon; Hélène Dumortier; Isabelle Douchet; Loïc Raffray; Christophe Richez; Estibaliz Lazaro; Pierre Duffau; Marie-Elise Truchetet; Liliane Khoryati; Patrick Mercié; Lionel Couzi; Pierre Merville; Thierry Schaeverbeke; Jean-François Viallard; Jean-Luc Pellegrin; Jean-François Moreau; Sylviane Muller; Sandy Zurawski; Robert L Coffman; Virginia Pascual; Hideki Ueno; Patrick Blanco
Journal:  Immunity       Date:  2015-06-09       Impact factor: 31.745

7.  Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.

Authors:  Eva V Acosta-Rodriguez; Laura Rivino; Jens Geginat; David Jarrossay; Marco Gattorno; Antonio Lanzavecchia; Federica Sallusto; Giorgio Napolitani
Journal:  Nat Immunol       Date:  2007-05-07       Impact factor: 25.606

8.  Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.

Authors:  Roza I Nurieva; Yeonseok Chung; Daehee Hwang; Xuexian O Yang; Hong Soon Kang; Li Ma; Yi-hong Wang; Stephanie S Watowich; Anton M Jetten; Qiang Tian; Chen Dong
Journal:  Immunity       Date:  2008-07-03       Impact factor: 31.745

9.  Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.

Authors:  Michela Locci; Colin Havenar-Daughton; Elise Landais; Jennifer Wu; Mark A Kroenke; Cecilia L Arlehamn; Laura F Su; Rafael Cubas; Mark M Davis; Alessandro Sette; Elias K Haddad; Pascal Poignard; Shane Crotty
Journal:  Immunity       Date:  2013-09-12       Impact factor: 31.745

10.  Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.

Authors:  Vladimir M Liarski; Natalya Kaverina; Anthony Chang; Daniel Brandt; Denisse Yanez; Lauren Talasnik; Gianluca Carlesso; Ronald Herbst; Tammy O Utset; Christine Labno; Yahui Peng; Yulei Jiang; Maryellen L Giger; Marcus R Clark
Journal:  Sci Transl Med       Date:  2014-04-02       Impact factor: 17.956
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  50 in total

Review 1.  CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.

Authors:  Andrea J Sant; Anthony T DiPiazza; Jennifer L Nayak; Ajitanuj Rattan; Katherine A Richards
Journal:  Immunol Rev       Date:  2018-07       Impact factor: 12.988

Review 2.  Functional RNAs control T follicular helper cells.

Authors:  Shingo Ichimiya; Ryuta Kamekura; Koji Kawata; Motonari Kamei; Tetsuo Himi
Journal:  J Hum Genet       Date:  2016-08-04       Impact factor: 3.172

3.  Ins and Outs of Antibodies.

Authors:  Sudhir Gupta
Journal:  J Clin Immunol       Date:  2016-05-12       Impact factor: 8.317

Review 4.  Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.

Authors:  Andrea J Sant; Katherine A Richards; Jennifer Nayak
Journal:  Curr Opin Immunol       Date:  2018-04-02       Impact factor: 7.486

5.  Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation.

Authors:  Jung J Hong; Eduardo L di Volpe Silveira; Praveen K Amancha; Siddappa N Byrareddy; Sanjeev Gumber; Kyu-Tae Chang; Aftab A Ansari; Francois Villinger
Journal:  AIDS       Date:  2017-08-24       Impact factor: 4.177

6.  A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses.

Authors:  Suresh Pallikkuth; Sidhartha Chaudhury; Pinyi Lu; Li Pan; Erik Jongert; Ulrike Wille-Reece; Savita Pahwa
Journal:  Elife       Date:  2020-04-29       Impact factor: 8.140

7.  Activated inducible co-stimulator-positive programmed cell death 1-positive follicular helper T cells indicate disease activity and severity in ulcerative colitis patients.

Authors:  Y Long; X Zhao; Chang Liu; C Xia; Chen Liu
Journal:  Clin Exp Immunol       Date:  2020-07-28       Impact factor: 4.330

Review 8.  Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue.

Authors:  Eli A Boritz; Daniel C Douek
Journal:  J Infect Dis       Date:  2017-03-15       Impact factor: 5.226

9.  Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status.

Authors:  Raisa Balbuena-Merle; Manjula Santhanakrishnan; Lesley Devine; David R Gibb; Christopher A Tormey; Alexa J Siddon; Susanna A Curtis; Patrick G Gallagher; Jason S Weinstein; Jeanne E Hendrickson
Journal:  Transfus Apher Sci       Date:  2020-04-27       Impact factor: 1.764

Review 10.  Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.

Authors:  Abhinav Seth; Joe Craft
Journal:  Curr Opin Immunol       Date:  2019-07-30       Impact factor: 7.486
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