Literature DB >> 23681096

The good, the bad and the ugly - TFH cells in human health and disease.

Stuart G Tangye1, Cindy S Ma, Robert Brink, Elissa K Deenick.   

Abstract

Antibody production is an important feature of the vertebrate immune system. Antibodies neutralize and clear pathogens, thereby protecting against infectious diseases. Such humoral immunity has great longevity, often persisting for the host's lifetime. Long-lived humoral immunity depends on help provided by CD4(+) T cells, namely T follicular helper (TFH) cells, which support the differentiation of antigen-specific B cells into memory and plasma cells. TFH cells are stringently regulated, as aberrant TFH cell activity is involved in immunopathologies such as autoimmunity, immunodeficiencies and lymphomas. The elucidation of the mechanisms that regulate TFH cell differentiation, function and fate should highlight targets for novel therapeutics.

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Year:  2013        PMID： 23681096     DOI： 10.1038/nri3447

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  125 in total

1.  Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Authors:  Cindy S Ma; Danielle T Avery; Anna Chan; Marcel Batten; Jacinta Bustamante; Stephanie Boisson-Dupuis; Peter D Arkwright; Alexandra Y Kreins; Diana Averbuch; Dan Engelhard; Klaus Magdorf; Sara S Kilic; Yoshiyuki Minegishi; Shigeaki Nonoyama; Martyn A French; Sharon Choo; Joanne M Smart; Jane Peake; Melanie Wong; Paul Gray; Matthew C Cook; David A Fulcher; Jean-Laurent Casanova; Elissa K Deenick; Stuart G Tangye
Journal:  Blood       Date:  2012-03-08       Impact factor: 22.113

Review 2.  Control systems and decision making for antibody production.

Authors:  Christopher C Goodnow; Carola G Vinuesa; Katrina L Randall; Fabienne Mackay; Robert Brink
Journal:  Nat Immunol       Date:  2010-07-20       Impact factor: 25.606

3.  Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

Authors:  Emily Hams; Mark J McCarron; Sylvie Amu; Hideo Yagita; Miyuki Azuma; Lieping Chen; Padraic G Fallon
Journal:  J Immunol       Date:  2011-04-13       Impact factor: 5.422

4.  Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

Authors:  Tyani D Chan; Katherine Wood; Jana R Hermes; Danyal Butt; Christopher J Jolly; Antony Basten; Robert Brink
Journal:  Immunity       Date:  2012-11-08       Impact factor: 31.745

5.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Authors:  Carola G Vinuesa; Matthew C Cook; Constanza Angelucci; Vicki Athanasopoulos; Lixin Rui; Kim M Hill; Di Yu; Heather Domaschenz; Belinda Whittle; Teresa Lambe; Ian S Roberts; Richard R Copley; John I Bell; Richard J Cornall; Christopher C Goodnow
Journal:  Nature       Date:  2005-05-26       Impact factor: 49.962

6.  Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques.

Authors:  Yin Xu; Chris Weatherall; Michelle Bailey; Sheilajen Alcantara; Robert De Rose; Jerome Estaquier; Kim Wilson; Kazuo Suzuki; Jacques Corbeil; David A Cooper; Stephen J Kent; Anthony D Kelleher; John Zaunders
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

7.  Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

Authors:  J Scott Hale; Ben Youngblood; Donald R Latner; Ata Ur Rasheed Mohammed; Lilin Ye; Rama S Akondy; Tuoqi Wu; Smita S Iyer; Rafi Ahmed
Journal:  Immunity       Date:  2013-04-11       Impact factor: 31.745

8.  Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity.

Authors:  C K Wong; Purple T Y Wong; L S Tam; Edmund K Li; D P Chen; Christopher W K Lam
Journal:  J Clin Immunol       Date:  2009-09-23       Impact factor: 8.317

9.  Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.

Authors:  Jérôme Pène; Jean-François Gauchat; Sandrine Lécart; Elodie Drouet; Paul Guglielmi; Vera Boulay; Adriana Delwail; Don Foster; Jean-Claude Lecron; Hans Yssel
Journal:  J Immunol       Date:  2004-05-01       Impact factor: 5.422

10.  B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

Authors:  Alex Karnowski; Stephane Chevrier; Gabrielle T Belz; Adele Mount; Dianne Emslie; Kathy D'Costa; David M Tarlinton; Axel Kallies; Lynn M Corcoran
Journal:  J Exp Med       Date:  2012-10-08       Impact factor: 14.307
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  211 in total

1.  miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Authors:  Ruozhen Hu; Dominique A Kagele; Thomas B Huffaker; Marah C Runtsch; Margaret Alexander; Jin Liu; Erin Bake; Wei Su; Matthew A Williams; Dinesh S Rao; Thomas Möller; Gwenn A Garden; June L Round; Ryan M O'Connell
Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

2.  ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.

Authors:  Jonathan M Weiss; Wei Chen; Melanie S Nyuydzefe; Alissa Trzeciak; Ryan Flynn; James R Tonra; Suzana Marusic; Bruce R Blazar; Samuel D Waksal; Alexandra Zanin-Zhorov
Journal:  Sci Signal       Date:  2016-07-19       Impact factor: 8.192

Review 3.  Regulation of intestinal IgA responses.

Authors:  Na Xiong; Shaomin Hu
Journal:  Cell Mol Life Sci       Date:  2015-04-03       Impact factor: 9.261

Review 4.  Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes.

Authors:  Birgit Knoechel; Jens G Lohr
Journal:  J Autoimmun       Date:  2013-07-21       Impact factor: 7.094

Review 5.  The dysfunction of T follicular helper cells.

Authors:  Rafael Cubas; Matthieu Perreau
Journal:  Curr Opin HIV AIDS       Date:  2014-09       Impact factor: 4.283

Review 6.  Interleukin-21: a double-edged sword with therapeutic potential.

Authors:  Rosanne Spolski; Warren J Leonard
Journal:  Nat Rev Drug Discov       Date:  2014-04-22       Impact factor: 84.694

Review 7.  Beyond regulatory T cells: the potential role for IL-2 to deplete T-follicular helper cells and treat autoimmune diseases.

Authors:  André Ballesteros-Tato
Journal:  Immunotherapy       Date:  2014       Impact factor: 4.196

8.  Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells.

Authors:  Caroline Theresa Seebauer; Stefan Brunner; Gabriel Glockzin; Pompiliu Piso; Petra Ruemmele; Hans-Juergen Schlitt; Edward Kenneth Geissler; Stefan Fichtner-Feigl; Rebecca Kesselring
Journal:  Oncoimmunology       Date:  2016-10-14       Impact factor: 8.110

9.  Differences in Tfh Cell Response Between the Graft and Spleen With Chronic Allograft Nephropathy.

Authors:  Jian Shi; Xianlin Xu; Fengbao Luo; Qianqian Shi; Xiaozhou He; Ying Xia
Journal:  Cell Transplant       Date:  2016-08-12       Impact factor: 4.064

Review 10.  Germinal centers and autoimmune disease in humans and mice.

Authors:  Anthony L DeFranco
Journal:  Immunol Cell Biol       Date:  2016-08-26       Impact factor: 5.126
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