Literature DB >> 2698428

Non-enzymic post-translational modification of proteins in aging. A review.

J J Harding1, H T Beswick, R Ajiboye, R Huby, R Blakytny, K C Rixon.   

Abstract

Various non-enzymic post-translational changes to proteins occur in vivo and some of these progress with aging. These changes are reviewed and linked to a number of age-related diseases, and to alterations in the charge distribution on protein surfaces. Modification by cyanate and by glucose 6-phosphate causes a partial unfolding of proteins, with loss of tertiary structure but retention of secondary structure. These products are reminiscent of the intermediate state observed during folding and unfolding of some proteins.

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Year:  1989        PMID： 2698428     DOI： 10.1016/0047-6374(89)90054-7

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  12 in total

1.  A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance.

Authors:  C Li; S Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

2.  Band 3 protein degradation by calpain is enhanced in erythrocytes of old people.

Authors:  N Schwarz-Ben Meir; T Glaser; N S Kosower
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

3.  Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.

Authors:  E Kim; J D Lowenson; D C MacLaren; S Clarke; S G Young
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

4.  Effect of aging on the chaperone-like function of human alpha-crystallin assessed by three methods.

Authors:  B K Derham; J J Harding
Journal:  Biochem J       Date:  1997-12-15       Impact factor: 3.857

5.  Preferential excretion of glycated albumin in C57BL-Ks-J mice: effects of diabetes.

Authors:  A Kowluru; R A Kowluru
Journal:  Experientia       Date:  1992-05-15

6.  Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state.

Authors:  Bei Li; Richard L Schowen; Elizabeth M Topp; Ronald T Borchardt
Journal:  AAPS J       Date:  2006-03-20       Impact factor: 4.009

7.  Oxidation of gamma II-crystallin solutions yields dimers with a high phase separation temperature.

Authors:  J Pande; A Lomakin; B Fine; O Ogun; I Sokolinski; G Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-14       Impact factor: 11.205

8.  Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.

Authors:  Katharina Diepold; Katrin Bomans; Michael Wiedmann; Boris Zimmermann; Andreas Petzold; Tilman Schlothauer; Robert Mueller; Bernd Moritz; Jan Olaf Stracke; Michael Mølhøj; Dietmar Reusch; Patrick Bulau
Journal:  PLoS One       Date:  2012-01-17       Impact factor: 3.240

9.  Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.

Authors:  Markus Haberger; Katrin Bomans; Katharina Diepold; Michaela Hook; Jana Gassner; Tilman Schlothauer; Adrian Zwick; Christian Spick; Jochen Felix Kepert; Brigitte Hienz; Michael Wiedmann; Hermann Beck; Philipp Metzger; Michael Mølhøj; Constanze Knoblich; Ulla Grauschopf; Dietmar Reusch; Patrick Bulau
Journal:  MAbs       Date:  2014-01-17       Impact factor: 5.857

10.  Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Authors:  Jasmin F Sydow; Florian Lipsmeier; Vincent Larraillet; Maximiliane Hilger; Bjoern Mautz; Michael Mølhøj; Jan Kuentzer; Stefan Klostermann; Juergen Schoch; Hans R Voelger; Joerg T Regula; Patrick Cramer; Apollon Papadimitriou; Hubert Kettenberger
Journal:  PLoS One       Date:  2014-06-24       Impact factor: 3.240
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