Literature DB >> 1601114

Preferential excretion of glycated albumin in C57BL-Ks-J mice: effects of diabetes.

A Kowluru1, R A Kowluru.   

Abstract

Urinary excretion of glycated albumin was quantitated in genetically hyperglycemic mice (C57BL-Ks-J, db/db mice), a model for non-insulin-dependent diabetes mellitus, and compared with their non-diabetic littermates. The data indicated a preferential excretion of glycated albumin in non-diabetic mice. This phenomenon of 'editing' of glycated albumin is decreased significantly in diabetic mice. Quantitative measurements of overall excretion of glycated albumin suggested that the loss of editing in diabetic mice is due to the dilution of glycated albumin by the unmodified albumin which is excreted in large amounts in diabetic mice. Therefore, the loss of editing observed in this model resembled the one we characterized in insulin-dependent diabetic humans and a streptozotocin-diabetic rat model.

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Year:  1992        PMID： 1601114     DOI： 10.1007/bf01928169

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Protein glycation: effects upon protein recognition by the proximal tubule.

Authors:  A Kowluru; R A Kowluru; S Solomon; L Martinez
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

2.  Micropinocytic ingestion of glycosylated albumin by isolated microvessels: possible role in pathogenesis of diabetic microangiopathy.

Authors:  S K Williams; J J Devenny; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

3.  Reduction of erythrocyte (Na+-K+)ATPase activity in type 1 (insulin-dependent) diabetic subjects and its activation by homologous plasma.

Authors:  P Finotti; P Palatini
Journal:  Diabetologia       Date:  1986-09       Impact factor: 10.122

4.  Diabetic neuropathy in db/db mice develops independently of changes in ATPase and aldose reductase. A biochemical and immunohistochemical study.

Authors:  R Bianchi; C Marelli; P Marini; M Fabris; C Triban; M G Fiori
Journal:  Diabetologia       Date:  1990-03       Impact factor: 10.122

5.  Glycation of calmodulin: chemistry and structural and functional consequences.

Authors:  R A Kowluru; D B Heidorn; S P Edmondson; M W Bitensky; A Kowluru; N W Downer; T W Whaley; J Trewhella
Journal:  Biochemistry       Date:  1989-03-07       Impact factor: 3.162

6.  Glycosyl albumin and diabetic microalbuminuria: demonstration of an altered renal handling.

Authors:  G M Ghiggeri; G Candiano; G Delfino; F Bianchini; C Queirolo
Journal:  Kidney Int       Date:  1984-03       Impact factor: 10.612

7.  Radioimmunoassay for urinary albumin.

Authors:  J Woo; M Floyd; D C Cannon; B Kahan
Journal:  Clin Chem       Date:  1978-09       Impact factor: 8.327

8.  Diabetes-obesity syndromes in mice.

Authors:  D L Coleman
Journal:  Diabetes       Date:  1982       Impact factor: 9.461

9.  Erythrocyte sodium-potassium ATPase activity and thiol metabolism in genetically hyperglycemic mice.

Authors:  R A Kowluru; A Kowluru
Journal:  Metabolism       Date:  1992-02       Impact factor: 8.694

10.  Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria.

Authors:  A Kowluru; R Kowluru; M W Bitensky; E J Corwin; S S Solomon; J D Johnson
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307
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  1 in total

1.  Covalent binding antibodies suppress advanced glycation: on the innate tier of adaptive immunity.

Authors:  T Shcheglova; S P Makker; A Tramontano
Journal:  Acta Naturae       Date:  2009-07       Impact factor: 1.845
  1 in total

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