Literature DB >> 2697941

The significance of chemically-induced hepatocellular altered foci in rat liver and application to carcinogen detection.

G M Williams1.   

Abstract

This review describes the pathogenesis and significance of chemically-induced hepatocellular altered foci in rat liver. The measurement of induction of foci can be used for carcinogen detection and the measurement of the modulation of foci by chemicals other than the inducing agent identifies enhancers or inhibitors of liver carcinogenesis.

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Year:  1989        PMID： 2697941     DOI： 10.1177/0192623389017004111

Source DB:  PubMed          Journal:  Toxicol Pathol        ISSN： 0192-6233            Impact factor:   1.902


  6 in total

1.  Iron chelator deferoxamine reduces preneoplastic lesions in liver induced by choline-deficient L-amino acid-defined diet in rats.

Authors:  I Sakaida; K Hironaka; K Uchida; K Okita
Journal:  Dig Dis Sci       Date:  1999-03       Impact factor: 3.199

2.  Loss of inhibitory growth regulation by TGF-beta1 in preneoplastic lesions in rat liver.

Authors:  I Sakaida; K Hironaka; K Uchida; K Okita
Journal:  Dig Dis Sci       Date:  2000-02       Impact factor: 3.199

3.  Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.

Authors:  H Yoshiji; D Nakae; T Kinugasa; M Matsuzaki; A Denda; T Tsujii; Y Konishi
Journal:  Br J Cancer       Date:  1991-11       Impact factor: 7.640

4.  Comparative histomorphological review of rat and human hepatocellular proliferative lesions.

Authors:  Bob Thoolen; Fiebo J W Ten Kate; Paul J van Diest; David E Malarkey; Susan A Elmore; Robert R Maronpot
Journal:  J Toxicol Pathol       Date:  2012-10-01       Impact factor: 1.628

5.  Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

Authors:  R R Maronpot; J F Foley; K Takahashi; T Goldsworthy; G Clark; A Tritscher; C Portier; G Lucier
Journal:  Environ Health Perspect       Date:  1993-12       Impact factor: 9.031

6.  Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.

Authors:  A Bishayee; M Chatterjee
Journal:  Br J Cancer       Date:  1995-06       Impact factor: 7.640
  6 in total

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