Literature DB >> 26979150

Genomics in CKD: Is This the Path Forward?

Girish N Nadkarni1, Carol R Horowitz2.   

Abstract

Recent advances in genomics and sequencing technology have led to a better understanding of genetic risk in CKD. Genetics could account in part for racial differences in treatment response for medications including antihypertensives and immunosuppressive medications due to its correlation with ancestry. However, there is still a substantial lag between generation of this knowledge and its adoption in routine clinical care. This review summarizes the recent advances in genomics and CKD, discusses potential reasons for its underutilization, and highlights potential avenues for application of genomic information to improve clinical care and outcomes in this particularly vulnerable population.
Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CKD; Disparities; Genetics; Genomics; Pharmacogenomics

Mesh：

Substances：

Year:  2016        PMID： 26979150      PMCID： PMC4795469          DOI： 10.1053/j.ackd.2016.01.017

Source DB:  PubMed          Journal:  Adv Chronic Kidney Dis        ISSN： 1548-5595            Impact factor:   3.620


  58 in total

Review 1.  Genome-wide association studies of chronic kidney disease: what have we learned?

Authors:  Conall M O'Seaghdha; Caroline S Fox
Journal:  Nat Rev Nephrol       Date:  2011-12-06       Impact factor: 28.314

Review 2.  Genetic contribution to variable human CYP3A-mediated metabolism.

Authors:  Jatinder K Lamba; Yvonne S Lin; Erin G Schuetz; Kenneth E Thummel
Journal:  Adv Drug Deliv Rev       Date:  2002-11-18       Impact factor: 15.470

Review 3.  The RAAS in the pathogenesis and treatment of diabetic nephropathy.

Authors:  Piero Ruggenenti; Paolo Cravedi; Giuseppe Remuzzi
Journal:  Nat Rev Nephrol       Date:  2010-05-04       Impact factor: 28.314

4.  Kidney function as a predictor of noncardiovascular mortality.

Authors:  Linda F Fried; Ronit Katz; Mark J Sarnak; Michael G Shlipak; Paulo H M Chaves; Nancy Swords Jenny; Catherine Stehman-Breen; Dan Gillen; Anthony J Bleyer; Calvin Hirsch; David Siscovick; Anne B Newman
Journal:  J Am Soc Nephrol       Date:  2005-10-26       Impact factor: 10.121

5.  APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.

Authors:  Jeffrey B Kopp; George W Nelson; Karmini Sampath; Randall C Johnson; Giulio Genovese; Ping An; David Friedman; William Briggs; Richard Dart; Stephen Korbet; Michele H Mokrzycki; Paul L Kimmel; Sophie Limou; Tejinder S Ahuja; Jeffrey S Berns; Justyna Fryc; Eric E Simon; Michael C Smith; Howard Trachtman; Donna M Michel; Jeffrey R Schelling; David Vlahov; Martin Pollak; Cheryl A Winkler
Journal:  J Am Soc Nephrol       Date:  2011-10-13       Impact factor: 10.121

6.  Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry.

Authors:  C R Horowitz; N S Abul-Husn; S Ellis; M A Ramos; R Negron; M Suprun; R E Zinberg; T Sabin; D Hauser; N Calman; E Bagiella; E P Bottinger
Journal:  Contemp Clin Trials       Date:  2015-12-30       Impact factor: 2.226

7.  ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans.

Authors:  S Ueda; P A Meredith; J J Morton; J M Connell; H L Elliott
Journal:  Circulation       Date:  1998-11-17       Impact factor: 29.690

Review 8.  Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention.

Authors:  Mark J Sarnak; Andrew S Levey; Anton C Schoolwerth; Josef Coresh; Bruce Culleton; L Lee Hamm; Peter A McCullough; Bertram L Kasiske; Ellie Kelepouris; Michael J Klag; Patrick Parfrey; Marc Pfeffer; Leopoldo Raij; David J Spinosa; Peter W Wilson
Journal:  Circulation       Date:  2003-10-28       Impact factor: 29.690

9.  Conversion from twice-daily tacrolimus capsules to once-daily extended-release tacrolimus (LCPT): a phase 2 trial of stable renal transplant recipients.

Authors:  A Osama Gaber; Rita R Alloway; Kenneth Bodziak; Bruce Kaplan; Suphamai Bunnapradist
Journal:  Transplantation       Date:  2013-07-27       Impact factor: 4.939

10.  Development and preliminary evaluation of an online educational video about whole-genome sequencing for research participants, patients, and the general public.

Authors:  Saskia C Sanderson; Sabrina A Suckiel; Micol Zweig; Erwin P Bottinger; Ethylin Wang Jabs; Lynne D Richardson
Journal:  Genet Med       Date:  2015-09-03       Impact factor: 8.822
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  4 in total

Review 1.  Prioritizing diversity in human genomics research.

Authors:  Lucia A Hindorff; Vence L Bonham; Lawrence C Brody; Margaret E C Ginoza; Carolyn M Hutter; Teri A Manolio; Eric D Green
Journal:  Nat Rev Genet       Date:  2017-11-20       Impact factor: 53.242

2.  Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists.

Authors:  Michal Mrug; Michelle S Bloom; Christine Seto; Meenakshi Malhotra; Hossein Tabriziani; Philippe Gauthier; Vicki Sidlow; Trudy McKanna; Paul R Billings
Journal:  Kidney Med       Date:  2021-10-05

3.  Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial.

Authors:  Girish N Nadkarni; Kezhen Fei; Michelle A Ramos; Diane Hauser; Emilia Bagiella; Stephen B Ellis; Saskia Sanderson; Stuart A Scott; Tatiana Sabin; Ebony Madden; Richard Cooper; Martin Pollak; Neil Calman; Erwin P Bottinger; Carol R Horowitz
Journal:  JAMA Netw Open       Date:  2022-03-01

4.  Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.

Authors:  Katherine M Spiech; Purnima R Tripathy; Alex M Woodcock; Nehal A Sheth; Kimberly S Collins; Karthik Kannegolla; Arjun D Sinha; Asif A Sharfuddin; Victoria M Pratt; Myda Khalid; David S Hains; Sharon M Moe; Todd C Skaar; Ranjani N Moorthi; Michael T Eadon
Journal:  Life (Basel)       Date:  2020-03-26
  4 in total

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