Literature DB >> 2697912

Structural and functional relationships between epidermal Langerhans cells and dendritic cells.

N Romani1, G Schuler.   

Abstract

Langerhans cells are dendritically shaped MHC-class II-bearing leukocytes which reside in the epidermis. During short-term culture, they develop into cells that are virtually indistinguishable from lymphoid dendritic cells with respect to morphology and phenotype, as well as function. It is hypothesized that Langerhans cells in situ represent immature precursors of dendritic cells.

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Year:  1989        PMID： 2697912     DOI： 10.1016/0923-2494(89)90050-3

Source DB:  PubMed          Journal:  Res Immunol        ISSN： 0923-2494


  4 in total

1.  Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

Authors:  E Kämpgen; N Koch; F Koch; P Stöger; C Heufler; G Schuler; N Romani
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

2.  Cellular components of the immune barrier in the spinal meninges and dorsal root ganglia of the normal rat: immunohistochemical (MHC class II) and electron-microscopic observations.

Authors:  J S Braun; B Kaissling; M Le Hir; W Zenker
Journal:  Cell Tissue Res       Date:  1993-08       Impact factor: 5.249

3.  Serum and mucosal immune responses to an inactivated influenza virus vaccine induced by epidermal powder immunization.

Authors:  D Chen; S B Periwal; K Larrivee; C Zuleger; C A Erickson; R L Endres; L G Payne
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

4.  Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

Authors:  H Stössel; F Koch; E Kämpgen; P Stöger; A Lenz; C Heufler; N Romani; G Schuler
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307
  4 in total

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