Literature DB >> 26976874

In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species.

Lujuan Gao1, Xiaozhen Ding2, Zhun Liu3, Qingzhi Wu2, Tongxiang Zeng2, Yi Sun4.   

Abstract

In vitro interactions of INK128, a target of rapamycin (TOR) kinase inhibitor, and antifungals, including itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin, against Aspergillus spp. were assessed with the broth microdilution checkerboard technique. Our results suggested synergistic effects between INK128 and all azoles tested, against multiple Aspergillus fumigatus and Aspergillus flavus isolates. However, no synergistic effects were observed when INK128 was combined with amphotericin B or caspofungin. No antagonism was observed for any combination.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26976874      PMCID： PMC4879397          DOI： 10.1128/AAC.02921-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  16 in total

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2.  Synergy, antagonism, and what the chequerboard puts between them.

Authors:  F C Odds
Journal:  J Antimicrob Chemother       Date:  2003-06-12       Impact factor: 5.790

3.  Polyphasic taxonomy of Aspergillus fumigatus and related species.

Authors:  Seung-Beom Hong; Seung-Joo Go; Hyeon-Dong Shin; Jens C Frisvad; Robert A Samson
Journal:  Mycologia       Date:  2005 Nov-Dec       Impact factor: 2.696

Review 4.  Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.

Authors:  José L Crespo; Michael N Hall
Journal:  Microbiol Mol Biol Rev       Date:  2002-12       Impact factor: 11.056

5.  In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes.

Authors:  S Narreddy; E Manavathu; P H Chandrasekar; G J Alangaden; S G Revankar
Journal:  J Antimicrob Chemother       Date:  2010-02-03       Impact factor: 5.790

6.  Phase-dependent antifungal activity against Aspergillus fumigatus developing multicellular filamentous biofilms.

Authors:  Eilidh Mowat; Sue Lang; Craig Williams; Elaine McCulloch; Brian Jones; Gordon Ramage
Journal:  J Antimicrob Chemother       Date:  2008-09-26       Impact factor: 5.790

7.  Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species.

Authors:  Dimitrios P Kontoyiannis; Russell E Lewis; Nir Osherov; Nathaniel D Albert; Gregory S May
Journal:  J Antimicrob Chemother       Date:  2003-02       Impact factor: 5.790

8.  Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice.

Authors:  Alonso Heredia; Nhut Le; Ronald B Gartenhaus; Edward Sausville; Sandra Medina-Moreno; Juan C Zapata; Charles Davis; Robert C Gallo; Robert R Redfield
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-13       Impact factor: 12.779

9.  The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Authors:  Andrew C Hsieh; Yi Liu; Merritt P Edlind; Nicholas T Ingolia; Matthew R Janes; Annie Sher; Evan Y Shi; Craig R Stumpf; Carly Christensen; Michael J Bonham; Shunyou Wang; Pingda Ren; Michael Martin; Katti Jessen; Morris E Feldman; Jonathan S Weissman; Kevan M Shokat; Christian Rommel; Davide Ruggero
Journal:  Nature       Date:  2012-02-22       Impact factor: 69.504

10.  Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models.

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Journal:  Breast Cancer Res Treat       Date:  2012-10-21       Impact factor: 4.624
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  3 in total

1.  In Vitro Interactions of Antifungal Agents and Everolimus Against Aspergillus Species.

Authors:  Huiping Jiang; Jianqun Xiong; Lihua Tan; Ping Jin; Yi Sun; Lianjuan Yang; Jingwen Tan
Journal:  Front Cell Infect Microbiol       Date:  2022-07-05       Impact factor: 6.073

2.  INK128 Exhibits Synergy with Azoles against Exophiala spp. and Fusarium spp.

Authors:  Lujuan Gao; Yi Sun; Chengyan He; Ming Li; Tongxiang Zeng; Qiaoyun Lu
Journal:  Front Microbiol       Date:  2016-10-20       Impact factor: 5.640

Review 3.  Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens.

Authors:  Sandeep Vellanki; Alexis E Garcia; Soo Chan Lee
Journal:  Front Mol Biosci       Date:  2020-10-16
  3 in total

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