Literature DB >> 12456783

Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.

José L Crespo1, Michael N Hall.   

Abstract

TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

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Year:  2002        PMID： 12456783      PMCID： PMC134654          DOI： 10.1128/MMBR.66.4.579-591.2002

Source DB:  PubMed          Journal:  Microbiol Mol Biol Rev        ISSN： 1092-2172            Impact factor:   11.056


  166 in total

1.  FAT: a novel domain in PIK-related kinases.

Authors:  R Bosotti; A Isacchi; E L Sonnhammer
Journal:  Trends Biochem Sci       Date:  2000-05       Impact factor: 13.807

Review 2.  TOR, a central controller of cell growth.

Authors:  T Schmelzle; M N Hall
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

3.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Authors:  Y Kabeya; N Mizushima; T Ueno; A Yamamoto; T Kirisako; T Noda; E Kominami; Y Ohsumi; T Yoshimori
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

4.  FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.

Authors:  R T Peterson; P A Beal; M J Comb; S L Schreiber
Journal:  J Biol Chem       Date:  2000-03-10       Impact factor: 5.157

5.  GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.

Authors:  Y Sagiv; A Legesse-Miller; A Porat; Z Elazar
Journal:  EMBO J       Date:  2000-04-03       Impact factor: 11.598

6.  Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.

Authors:  G P Cosentino; T Schmelzle; A Haghighat; S B Helliwell; M N Hall; N Sonenberg
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

7.  Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity.

Authors:  A Bernal; D A Kimbrell
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

8.  A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Authors:  A Sekulić; C C Hudson; J L Homme; P Yin; D M Otterness; L M Karnitz; R T Abraham
Journal:  Cancer Res       Date:  2000-07-01       Impact factor: 12.701

9.  Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.

Authors:  S Oldham; J Montagne; T Radimerski; G Thomas; E Hafen
Journal:  Genes Dev       Date:  2000-11-01       Impact factor: 11.361

10.  Tor-mediated induction of autophagy via an Apg1 protein kinase complex.

Authors:  Y Kamada; T Funakoshi; T Shintani; K Nagano; M Ohsumi; Y Ohsumi
Journal:  J Cell Biol       Date:  2000-09-18       Impact factor: 10.539
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  144 in total

Review 1.  Calorie restriction: what recent results suggest for the future of ageing research.

Authors:  Daniel L Smith; Tim R Nagy; David B Allison
Journal:  Eur J Clin Invest       Date:  2010-05       Impact factor: 4.686

2.  TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.

Authors:  Neus Colomina; Yuhui Liu; Martí Aldea; Eloi Garí
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

3.  Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by rapamycin inhibition of Tor1/2 in Saccharomyces cerevisiae.

Authors:  Kathleen H Cox; Ajit Kulkarni; Jennifer J Tate; Terrance G Cooper
Journal:  J Biol Chem       Date:  2003-12-16       Impact factor: 5.157

4.  Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism.

Authors:  Jennifer J Tate; Terrance G Cooper
Journal:  J Biol Chem       Date:  2003-07-07       Impact factor: 5.157

5.  Synergistic operation of four cis-acting elements mediate high level DAL5 transcription in Saccharomyces cerevisiae.

Authors:  Rajendra Rai; Jon R Daugherty; Jennifer J Tate; Thomas D Buford; Terrance G Cooper
Journal:  FEMS Yeast Res       Date:  2004-10       Impact factor: 2.796

6.  Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

Authors:  Rosa M Marion; Aviv Regev; Eran Segal; Yoseph Barash; Daphne Koller; Nir Friedman; Erin K O'Shea
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-07       Impact factor: 11.205

Review 7.  Staying alive: metabolic adaptations to quiescence.

Authors:  James R Valcourt; Johanna M S Lemons; Erin M Haley; Mina Kojima; Olukunle O Demuren; Hilary A Coller
Journal:  Cell Cycle       Date:  2012-05-01       Impact factor: 4.534

8.  Stb3 plays a role in the glucose-induced transition from quiescence to growth in Saccharomyces cerevisiae.

Authors:  Dritan Liko; Michael K Conway; Douglas S Grunwald; Warren Heideman
Journal:  Genetics       Date:  2010-04-12       Impact factor: 4.562

9.  Systematic identification of gene annotation errors in the widely used yeast mutation collections.

Authors:  Taly Ben-Shitrit; Nir Yosef; Keren Shemesh; Roded Sharan; Eytan Ruppin; Martin Kupiec
Journal:  Nat Methods       Date:  2012-02-05       Impact factor: 28.547

Review 10.  Natural products as chemical probes.

Authors:  Erin E Carlson
Journal:  ACS Chem Biol       Date:  2010-07-16       Impact factor: 5.100
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