Literature DB >> 26976861

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus.

Arya Gupta1, Carmine Monteferrante2, Dace Rasina3, Gundars Leitis3, Christopher P Randall1, Jennifer H Tomlinson1, Aigars Jirgensons3, Wil H F Goessens2, John P Hays2, Alex J O'Neill4.   

Abstract

GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in phase II clinical trials. Here, we report the identification of a clinical isolate of Staphylococcus aureus that exhibits reduced susceptibility to GSK2251052 without prior exposure to the compound and demonstrate that this phenotype is attributable to a single amino acid polymorphism (P329) within the editing domain of LeuRS.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26976861      PMCID： PMC4862542          DOI： 10.1128/AAC.02940-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

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Authors:  A J O'Neill
Journal:  Lett Appl Microbiol       Date:  2010-06-10       Impact factor: 2.858

2.  Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

Authors:  Karen O'Dwyer; Aaron T Spivak; Karen Ingraham; Sharon Min; David J Holmes; Charles Jakielaszek; Stephen Rittenhouse; Alan L Kwan; George P Livi; Ganesh Sathe; Elizabeth Thomas; Stephanie Van Horn; Linda A Miller; Monique Twynholm; John Tomayko; Marybeth Dalessandro; Madelyn Caltabiano; Nicole E Scangarella-Oman; James R Brown
Journal:  Antimicrob Agents Chemother       Date:  2014-10-27       Impact factor: 5.191

3.  Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

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Journal:  Antimicrob Agents Chemother       Date:  2013-01-07       Impact factor: 5.191

4.  A simple plasmid-based system that allows rapid generation of tightly controlled gene expression in Staphylococcus aureus.

Authors:  Andrew T F Liew; Torsten Theis; Slade O Jensen; Jorge Garcia-Lara; Simon J Foster; Neville Firth; Peter J Lewis; Elizabeth J Harry
Journal:  Microbiology (Reading)       Date:  2010-11-25       Impact factor: 2.777

5.  Antimicrobial activity of a novel peptide deformylase inhibitor, LBM415, tested against respiratory tract and cutaneous infection pathogens: a global surveillance report (2003-2004).

Authors:  Amy A Watters; Ronald N Jones; Jennifer A Leeds; Gerald Denys; Helio S Sader; Thomas R Fritsche
Journal:  J Antimicrob Chemother       Date:  2006-03-20       Impact factor: 5.790

6.  An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Authors:  Fernando L Rock; Weimin Mao; Anya Yaremchuk; Mikhail Tukalo; Thibaut Crépin; Huchen Zhou; Yong-Kang Zhang; Vincent Hernandez; Tsutomu Akama; Stephen J Baker; Jacob J Plattner; Lucy Shapiro; Susan A Martinis; Stephen J Benkovic; Stephen Cusack; M R K Alley
Journal:  Science       Date:  2007-06-22       Impact factor: 47.728

7.  sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.

Authors:  Malcolm J Horsburgh; Joanne L Aish; Ian J White; Les Shaw; James K Lithgow; Simon J Foster
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490
  7 in total
  5 in total

1.  Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.

Authors:  Sergey V Melnikov; David L Stevens; Xian Fu; Hui Si Kwok; Jin-Tao Zhang; Yue Shen; Jeffery Sabina; Kevin Lee; Harry Lee; Dieter Söll
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-13       Impact factor: 11.205

2.  Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.

Authors:  Christopher P Randall; Dace Rasina; Aigars Jirgensons; Alex J O'Neill
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

3.  In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum.

Authors:  Diletta Mazzantini; Francesco Celandroni; Marco Calvigioni; Antonella Lupetti; Emilia Ghelardi
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

4.  N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.

Authors:  Michael H Charlton; Rihards Aleksis; Adélaïde Saint-Leger; Arya Gupta; Einars Loza; Lluís Ribas de Pouplana; Ilze Kaula; Daina Gustina; Marina Madre; Daina Lola; Kristaps Jaudzems; Grace Edmund; Christopher P Randall; Louise Kime; Alex J O'Neill; Wil Goessens; Aigars Jirgensons; Paul W Finn
Journal:  ACS Med Chem Lett       Date:  2018-01-18       Impact factor: 4.345

Review 5.  Antibiotics in the clinical pipeline in October 2019.

Authors:  Mark S Butler; David L Paterson
Journal:  J Antibiot (Tokyo)       Date:  2020-03-10       Impact factor: 2.649
  5 in total

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