Literature DB >> 26975506

Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.

Alina Kassenbrock, Neil Vasdev, Steven H Liang1.   

Abstract

Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a developing area of preclinical and clinical research. The present review focuses on recent advances with radiochemistry, preclinical and clinical PET imaging studies of three receptors that are actively pursued in neuropsychiatric drug discovery: namely the γ-aminobutyric acid-benzodiazapine (GABA) receptor, nicotinic acetylcholine receptor (nAChR), and N-methyl-D-aspartate (NMDA) receptor. Recent efforts to develop new PET radioligands for these targets with improved brain uptake, selectivity, stability and pharmacokinetics are highlighted.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26975506      PMCID： PMC4950862          DOI： 10.2174/1568026616666160315142457

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  109 in total

Review 1.  Associations of regional GABA and glutamate with intrinsic and extrinsic neural activity in humans—a review of multimodal imaging studies.

Authors:  Niall W Duncan; Christine Wiebking; Georg Northoff
Journal:  Neurosci Biobehav Rev       Date:  2014-07-24       Impact factor: 8.989

2.  Microwave-assisted radiosynthesis of [(18) F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist.

Authors:  Hayden T Ravert; Daniel P Holt; Yongjun Gao; Andrew G Horti; Robert F Dannals
Journal:  J Labelled Comp Radiopharm       Date:  2015-02-26       Impact factor: 1.921

3.  Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancy.

Authors:  Dean F Wong; Hiroto Kuwabara; Martin Pomper; Daniel P Holt; James R Brasic; Noble George; Boris Frolov; William Willis; Yongjun Gao; Heather Valentine; Ayon Nandi; Lorena Gapasin; Robert F Dannals; Andrew G Horti
Journal:  Mol Imaging Biol       Date:  2014-10       Impact factor: 3.488

4.  Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors.

Authors:  Johannes A M Christiaans; Pieter J Klein; Athanasios Metaxas; Esther J M Kooijman; Robert C Schuit; Josée E Leysen; Adriaan A Lammertsma; Bart N M van Berckel; Albert D Windhorst
Journal:  Nucl Med Biol       Date:  2014-05-10       Impact factor: 2.408

Review 5.  Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway.

Authors:  Chao Deng; Bo Pan; Martin Engel; Xu-Feng Huang
Journal:  Psychopharmacology (Berl)       Date:  2013-02-07       Impact factor: 4.530

6.  New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation.

Authors:  Daisy van Veghel; Jan Cleynhens; Larry V Pearce; Ian A DeAndrea-Lazarus; Peter M Blumberg; Koen Van Laere; Alfons Verbruggen; Guy Bormans
Journal:  ACS Chem Neurosci       Date:  2013-02-19       Impact factor: 4.418

7.  Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study.

Authors:  Yu Kyeong Kim; Eun Joo Yang; Kyehee Cho; Jong Youb Lim; Nam-Jong Paik
Journal:  Neurorehabil Neural Repair       Date:  2014-01-24       Impact factor: 3.919

Review 8.  Neural nAChRs PET imaging probes.

Authors:  Ye-Xiong Mo; Ya-Fu Yin; Ya-Ming Li
Journal:  Nucl Med Commun       Date:  2014-02       Impact factor: 1.690

Review 9.  Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography.

Authors:  Andrew G Horti; Yongjun Gao; Hiroto Kuwabara; Robert F Dannals
Journal:  Life Sci       Date:  2009-03-18       Impact factor: 5.037

10.  The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study.

Authors:  Maria Andreina Mendez; Jamie Horder; Jim Myers; Suzanne Coghlan; Paul Stokes; David Erritzoe; Oliver Howes; Anne Lingford-Hughes; Declan Murphy; David Nutt
Journal:  Neuropharmacology       Date:  2012-04-21       Impact factor: 5.250
View more
  7 in total

1.  Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.

Authors:  Lucia Tamborini; Ying Chen; Catherine A Foss; Andrea Pinto; Andrew G Horti; Stephen F Traynelis; Carlo De Micheli; Ronnie C Mease; Kasper B Hansen; Paola Conti; Martin G Pomper
Journal:  J Med Chem       Date:  2016-12-06       Impact factor: 7.446

Review 2.  Classics in Neuroimaging: Development of Positron Emission Tomography Tracers for Imaging the GABAergic Pathway.

Authors:  Emily Murrell; Jonathan M Pham; Alexandra R Sowa; Allen F Brooks; Michael R Kilbourn; Peter J H Scott; Neil Vasdev
Journal:  ACS Chem Neurosci       Date:  2020-06-24       Impact factor: 4.418

Review 3.  Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.

Authors:  Hualong Fu; Zhen Chen; Lee Josephson; Zijing Li; Steven H Liang
Journal:  J Med Chem       Date:  2018-08-27       Impact factor: 7.446

4.  Thalamocortical bistable switch as a theoretical model of fibromyalgia pathogenesis inferred from a literature survey.

Authors:  Ilaria Demori; Giulia Giordano; Viviana Mucci; Serena Losacco; Lucio Marinelli; Paolo Massobrio; Franco Blanchini; Bruno Burlando
Journal:  J Comput Neurosci       Date:  2022-07-11       Impact factor: 1.453

5.  Evaluation of 11C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats.

Authors:  Lisheng Cai; Jeih-San Liow; Cheryl L Morse; Sanjay Telu; Riley Davies; Michael P Frankland; Sami S Zoghbi; Ken Cheng; Matthew D Hall; Robert B Innis; Victor W Pike
Journal:  J Nucl Med       Date:  2020-01-10       Impact factor: 10.057

6.  Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[3 H]3 methoxy phenyl)-N'-methylguanidine ([3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.

Authors:  Athanasios Metaxas; Bart N M van Berckel; Pieter J Klein; Joost Verbeek; Emily C Nash; Esther J M Kooijman; Véronique A Renjaän; Sandeep S V Golla; Ronald Boellaard; Johannes A M Christiaans; Albert D Windhorst; Josée E Leysen
Journal:  Pharmacol Res Perspect       Date:  2019-02

Review 7.  Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Authors:  Vidya Narayanaswami; Kenneth Dahl; Vadim Bernard-Gauthier; Lee Josephson; Paul Cumming; Neil Vasdev
Journal:  Mol Imaging       Date:  2018 Jan-Dec       Impact factor: 4.488
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.