| Literature DB >> 25720955 |
Hayden T Ravert1, Daniel P Holt, Yongjun Gao, Andrew G Horti, Robert F Dannals.
Abstract
An improvement of the original radiochemical synthesis of [(18) F]ASEM, an α7-nicotinic acetylcholinergic receptor radioligand, is reported. The new procedure utilizes microwave-assisted radiofluorination. In addition, a new preparative HPLC method was developed to eliminate a chemical impurity in the final product. Quality control procedures were also enhanced to improve detection of product with enhanced resolution of potential impurities. [(18) F]ASEM was produced in 20.1 ± 8.9% non-decay corrected (NDC) yield with an average synthesis time of 57 min and an average specific radioactivity of 856 ± 332 GBq/µmol (23 ± 9 Ci/µmol).Entities:
Keywords: PET chemistry; [18F]ASEM; microwave; radiosynthesis; α7-nAChR
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Year: 2015 PMID： 25720955 DOI： 10.1002/jlcr.3275
Source DB: PubMed Journal: J Labelled Comp Radiopharm ISSN： 0362-4803 Impact factor: 1.921