Literature DB >> 25742088

Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth.

Karina M Butler1, Patrick Gavin, Suzie Coughlan, Annette Rochford, Sinead Mc Donagh, Orla Cunningham, Hannah Poulsom, Sarah A Watters, Nigel Klein.   

Abstract

Attention has focused on the possibility of cure for HIV infected infants if treated promptly after delivery. The "Mississippi baby," who had very prolonged remission after antiretroviral discontinuation, may represent a unique situation. We report an infant treated from birth, who seroreverted, remained virologically suppressed, and had undetectable HIV-1 RNA and DNA at 4 years of age, yet experienced virologic rebound within days of discontinuation of antiretroviral therapy.

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Year:  2015        PMID: 25742088     DOI: 10.1097/INF.0000000000000570

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN: 0891-3668            Impact factor:   2.129


  26 in total

1.  Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed.

Authors:  Louise Kuhn; Diana B Schramm; Stephanie Shiau; Renate Strehlau; Francoise Pinillos; Karl Technau; Ashraf Coovadia; Elaine J Abrams; Adrian Puren; Caroline T Tiemessen
Journal:  AIDS       Date:  2015-06-01       Impact factor: 4.177

Review 2.  Kill: boosting HIV-specific immune responses.

Authors:  Lydie Trautmann
Journal:  Curr Opin HIV AIDS       Date:  2016-07       Impact factor: 4.283

3.  Reactivation Kinetics of HIV-1 and Susceptibility of Reactivated Latently Infected CD4+ T Cells to HIV-1-Specific CD8+ T Cells.

Authors:  Victoria E K Walker-Sperling; Valerie J Cohen; Patrick M Tarwater; Joel N Blankson
Journal:  J Virol       Date:  2015-07-15       Impact factor: 5.103

4.  Intact HIV Proviruses Persist in Children Seven to Nine Years after Initiation of Antiretroviral Therapy in the First Year of Life.

Authors:  Mary Grace Katusiime; Elias K Halvas; Imogen Wright; Kevin Joseph; Michael J Bale; Bronwyn Kirby-McCullough; Susan Engelbrecht; Wei Shao; Wei-Shau Hu; Mark F Cotton; John W Mellors; Mary F Kearney; Gert U van Zyl
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103

5.  Viremic relapse after HIV-1 remission in a perinatally infected child.

Authors:  Katherine Luzuriaga; Hannah Gay; Carrie Ziemniak; Keri B Sanborn; Mohan Somasundaran; Kaitlin Rainwater-Lovett; John W Mellors; Daniel Rosenbloom; Deborah Persaud
Journal:  N Engl J Med       Date:  2015-02-19       Impact factor: 91.245

6.  A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads.

Authors:  Kelly A Metcalf Pate; Christopher W Pohlmeyer; Victoria E Walker-Sperling; Jeremy B Foote; Kevin M Najarro; Catherine G Cryer; Maria Salgado; Lucio Gama; Elizabeth L Engle; Erin N Shirk; Suzanne E Queen; Stanley Chioma; Meghan S Vermillion; Brandon Bullock; Ming Li; Claire E Lyons; Robert J Adams; M Christine Zink; Janice E Clements; Joseph L Mankowski; Joel N Blankson
Journal:  J Infect Dis       Date:  2015-04-15       Impact factor: 5.226

Review 7.  Paediatric HIV infection: the potential for cure.

Authors:  Philip J Goulder; Sharon R Lewin; Ellen M Leitman
Journal:  Nat Rev Immunol       Date:  2016-03-14       Impact factor: 53.106

Review 8.  Advances and hope for perinatal HIV remission and cure in children and adolescents.

Authors:  Kaitlin Rainwater-Lovett; Priyanka Uprety; Deborah Persaud
Journal:  Curr Opin Pediatr       Date:  2016-02       Impact factor: 2.856

9.  Paediatric HIV: Progress on Prevention, Treatment and Cure.

Authors:  Maria H Kim; Saeed Ahmed; Elaine J Abrams
Journal:  Curr Pediatr Rep       Date:  2015-07-22

10.  Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.

Authors:  Maud Mavigner; Jakob Habib; Claire Deleage; Elias Rosen; Cameron Mattingly; Katherine Bricker; Angela Kashuba; Franck Amblard; Raymond F Schinazi; Benton Lawson; Thomas H Vanderford; Sherrie Jean; Joyce Cohen; Colleen McGary; Mirko Paiardini; Matthew P Wood; Donald L Sodora; Guido Silvestri; Jacob Estes; Ann Chahroudi
Journal:  J Virol       Date:  2018-08-29       Impact factor: 5.103

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