BACKGROUND: T3 laryngeal cancer encompasses heterogeneous lesions whose treatment is still debated. The purpose of this study was to evaluate transoral laser microsurgery (TLM) in management of selected T3 glottic and supraglottic cancers. METHODS: Fifty-six patients with selected T3 glottic and supraglottic squamous cell carcinomas (SCCs) treated by TLM ± selective neck dissection ± adjuvant therapy were evaluated in terms of overall survival (OS), disease-free survival (DFS), and organ preservation rates. RESULTS: For the entire cohort, 5-year OS and DFS were 63.3% and 72.4%, whereas they were 65.2% and 72.9% for glottic and 59.3% and 76.3% for supraglottic SCC, respectively. No patient required permanent tracheostomy and 1 patient was gastrostomy tube-dependent at last follow-up. CONCLUSION: TLM ± selective neck dissection ± adjuvant (chemo)radiotherapy for selected T3 glottic and supraglottic SCC represents an effective alternative treatment to open partial laryngectomies and nonsurgical organ preservation protocols, particularly in elderly and frail patients.
BACKGROUND: T3 laryngeal cancer encompasses heterogeneous lesions whose treatment is still debated. The purpose of this study was to evaluate transoral laser microsurgery (TLM) in management of selected T3 glottic and supraglottic cancers. METHODS: Fifty-six patients with selected T3 glottic and supraglottic squamous cell carcinomas (SCCs) treated by TLM ± selective neck dissection ± adjuvant therapy were evaluated in terms of overall survival (OS), disease-free survival (DFS), and organ preservation rates. RESULTS: For the entire cohort, 5-year OS and DFS were 63.3% and 72.4%, whereas they were 65.2% and 72.9% for glottic and 59.3% and 76.3% for supraglottic SCC, respectively. No patient required permanent tracheostomy and 1 patient was gastrostomy tube-dependent at last follow-up. CONCLUSION:TLM ± selective neck dissection ± adjuvant (chemo)radiotherapy for selected T3 glottic and supraglottic SCC represents an effective alternative treatment to open partial laryngectomies and nonsurgical organ preservation protocols, particularly in elderly and frail patients.
Authors: Jennifer R Cracchiolo; Anne F Klassen; Danny A Young-Afat; Claudia R Albornoz; Stefan J Cano; Snehal G Patel; Andrea L Pusic; Evan Matros Journal: Cancer Date: 2018-11-30 Impact factor: 6.860
Authors: Andrea Colizza; Massimo Ralli; Arianna Di Stadio; Francesca Cambria; Federica Zoccali; Fabrizio Cialente; Diletta Angeletti; Antonio Greco; Marco de Vincentiis Journal: J Clin Med Date: 2022-08-14 Impact factor: 4.964
Authors: Cesare Piazza; Marta Filauro; Alberto Paderno; Filippo Marchi; Pietro Perotti; Riccardo Morello; Stefano Taboni; Giampiero Parrinello; Fabiola Incandela; Andrea Iandelli; Francesco Missale; Giorgio Peretti Journal: Front Oncol Date: 2018-05-22 Impact factor: 6.244