Literature DB >> 26969973

The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.

Marek Mlodzik1.   

Abstract

Dishevelled (Dsh) is a key component of Wnt-signaling pathways and possibly also has other functional requirements. Dsh appears to be a key factor to interpret Wnt signals coming via the Wnt-receptor family, the Frizzled proteins, from the plasma membrane and route them into the correct intracellular pathways. However, how Dsh is regulated to relay signal flow to specific and distinct cellular responses upon interaction with the same Wnt-receptor family remains very poorly understood.
© 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Dishevelled; Frizzled; Planar cell polarity; Signaling specificity; Wnt signaling

Mesh：

Substances：

Year:  2016        PMID： 26969973      PMCID： PMC4939608          DOI： 10.1016/bs.ctdb.2015.11.027

Source DB:  PubMed          Journal:  Curr Top Dev Biol        ISSN： 0070-2153            Impact factor:   4.897


  67 in total

Review 1.  Planar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross-talk.

Authors:  M Mlodzik
Journal:  EMBO J       Date:  1999-12-15       Impact factor: 11.598

2.  Signaling specificity by Frizzled receptors in Drosophila.

Authors:  M Boutros; J Mihaly; T Bouwmeester; M Mlodzik
Journal:  Science       Date:  2000-06-09       Impact factor: 47.728

3.  Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.

Authors:  Antonia Borovina; Simone Superina; Daniel Voskas; Brian Ciruna
Journal:  Nat Cell Biol       Date:  2010-03-21       Impact factor: 28.824

4.  Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.

Authors:  Ekatherina Serysheva; Hebist Berhane; Luca Grumolato; Kubilay Demir; Sophie Balmer; Maxime Bodak; Michael Boutros; Stuart Aaronson; Marek Mlodzik; Andreas Jenny
Journal:  EMBO Rep       Date:  2013-06-25       Impact factor: 8.807

5.  Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.

Authors:  Jaskirat Singh; Wang A Yanfeng; Luca Grumolato; Stuart A Aaronson; Marek Mlodzik
Journal:  Genes Dev       Date:  2010-09-13       Impact factor: 11.361

6.  Dishevelled controls cell polarity during Xenopus gastrulation.

Authors:  J B Wallingford; B A Rowning; K M Vogeli; U Rothbächer; S E Fraser; R M Harland
Journal:  Nature       Date:  2000-05-04       Impact factor: 49.962

7.  Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila.

Authors:  Jun Wu; Andreas Jenny; Ivana Mirkovic; Marek Mlodzik
Journal:  Mech Dev       Date:  2007-10-17       Impact factor: 1.882

8.  Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.

Authors:  D J Sussman; J Klingensmith; P Salinas; P S Adams; R Nusse; N Perrimon
Journal:  Dev Biol       Date:  1994-11       Impact factor: 3.582

9.  Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.

Authors:  William J Gault; Patricio Olguin; Ursula Weber; Marek Mlodzik
Journal:  J Cell Biol       Date:  2012-03-05       Impact factor: 10.539

10.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

Authors:  A H Brand; N Perrimon
Journal:  Development       Date:  1993-06       Impact factor: 6.868
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  38 in total

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Authors:  Ali Vural; Ersin Fadillioglu; Fatih Kelesoglu; Dzwokai Ma; Stephen M Lanier
Journal:  J Cell Sci       Date:  2018-12-05       Impact factor: 5.285

2.  Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Authors:  Jana Valnohova; Maria Kowalski-Jahn; Roger K Sunahara; Gunnar Schulte
Journal:  J Biol Chem       Date:  2018-09-20       Impact factor: 5.157

3.  Eph signaling in mitotic spindle orientation: what´s your angle here?

Authors:  Maribel Franco; Ana Carmena
Journal:  Cell Cycle       Date:  2019-09-01       Impact factor: 4.534

4.  Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.

Authors:  Jing Qi; Ho-Jin Lee; Audrey Saquet; Xiao-Ning Cheng; Ming Shao; Jie J Zheng; De-Li Shi
Journal:  J Biol Chem       Date:  2017-02-21       Impact factor: 5.157

5.  PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling.

Authors:  Adnan Shami Shah; Alex G Batrouni; Dongsung Kim; Amith Punyala; Wendy Cao; Chun Han; Michael L Goldberg; Marcus B Smolka; Jeremy M Baskin
Journal:  Cell Rep       Date:  2019-05-14       Impact factor: 9.423

Review 6.  Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates.

Authors:  Kristina N Schaefer; Mark Peifer
Journal:  Dev Cell       Date:  2019-02-25       Impact factor: 12.270

7.  Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2.

Authors:  Ali Vural; Stephen M Lanier
Journal:  J Cell Sci       Date:  2020-09-04       Impact factor: 5.285

Review 8.  Dishevelled: A masterful conductor of complex Wnt signals.

Authors:  Monica Sharma; Isabel Castro-Piedras; Glenn E Simmons; Kevin Pruitt
Journal:  Cell Signal       Date:  2018-03-17       Impact factor: 4.315

Review 9.  Mechanisms of Wnt signaling and control.

Authors:  Stephanie Grainger; Karl Willert
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2018-03-30

Review 10.  WNT Signaling in Cardiac and Vascular Disease.

Authors:  Sébastien Foulquier; Evangelos P Daskalopoulos; Gentian Lluri; Kevin C M Hermans; Arjun Deb; W Matthijs Blankesteijn
Journal:  Pharmacol Rev       Date:  2018-01       Impact factor: 25.468
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