Martina Papmeyer1,2, Irène Würsch1, Erich Studerus1, Rolf-Dieter Stieglitz1, Anita Riecher-Rössler3. 1. Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Kornhausgasse 7, 4051, Basel, Switzerland. 2. Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland. 3. Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Kornhausgasse 7, 4051, Basel, Switzerland. Anita.Riecher@upkbs.ch.
Abstract
BACKGROUND: Several indicators of heightened vulnerability to psychosis and relevant stressors have been identified. However, it has rarely been studied prospectively to what extent these vulnerability factors are in fact more frequently present in individuals with an at-risk mental state for psychosis. Moreover, it remains unknown whether any of these contribute to the prediction of psychosis onset in at-risk mental state individuals. METHODS: There were 28 healthy controls, 86 first-episode psychosis patients and 127 at-risk mental state individuals recruited within the Basel "Früherkennung von Psychosen" project. Relative frequencies of selected vulnerability factors for psychosis were compared between healthy controls, psychosis patients, those at-risk mental state individuals with subsequent psychosis onset (n = 31) and those without subsequent psychosis onset (n = 55). Survival analyses were applied to determine associations between time to transition to psychosis and vulnerability factors in all 127 at-risk mental state individuals. RESULTS: The vulnerability factors/indicators such as "difficulties during school education or vocational training", "difficulties during employment", "being single", "difficulties with intimate relationships" and "being burdened with specific stressful situations" were more commonly found in the at-risk mental state and first-episode psychosis group than in healthy controls. CONCLUSIONS: At-risk mental state and first-episode psychosis individuals more frequently present with vulnerability factors. Individual vulnerability factors appear, however, not to be predictive for an onset of psychosis.
BACKGROUND: Several indicators of heightened vulnerability to psychosis and relevant stressors have been identified. However, it has rarely been studied prospectively to what extent these vulnerability factors are in fact more frequently present in individuals with an at-risk mental state for psychosis. Moreover, it remains unknown whether any of these contribute to the prediction of psychosis onset in at-risk mental state individuals. METHODS: There were 28 healthy controls, 86 first-episode psychosispatients and 127 at-risk mental state individuals recruited within the Basel "Früherkennung von Psychosen" project. Relative frequencies of selected vulnerability factors for psychosis were compared between healthy controls, psychosispatients, those at-risk mental state individuals with subsequent psychosis onset (n = 31) and those without subsequent psychosis onset (n = 55). Survival analyses were applied to determine associations between time to transition to psychosis and vulnerability factors in all 127 at-risk mental state individuals. RESULTS: The vulnerability factors/indicators such as "difficulties during school education or vocational training", "difficulties during employment", "being single", "difficulties with intimate relationships" and "being burdened with specific stressful situations" were more commonly found in the at-risk mental state and first-episode psychosis group than in healthy controls. CONCLUSIONS: At-risk mental state and first-episode psychosis individuals more frequently present with vulnerability factors. Individual vulnerability factors appear, however, not to be predictive for an onset of psychosis.
Authors: Anthony P Morrison; Paul French; Shôn W Lewis; Morwenna Roberts; Shreeta Raja; Sandra T Neil; Sophie Parker; Joanne Green; Aoiffe Kilcommons; Lara Walford; Richard P Bentall Journal: Psychol Med Date: 2006-07-03 Impact factor: 7.723
Authors: Mary Cannon; Avshalom Caspi; Terrie E Moffitt; HonaLee Harrington; Alan Taylor; Robin M Murray; Richie Poulton Journal: Arch Gen Psychiatry Date: 2002-05
Authors: I Isohanni; M R Järvelin; P Nieminen; P Jones; P Rantakallio; J Jokelainen; M Isohanni Journal: Psychol Med Date: 1998-07 Impact factor: 7.723
Authors: Jim van Os; Bart P Rutten; Inez Myin-Germeys; Philippe Delespaul; Wolfgang Viechtbauer; Catherine van Zelst; Richard Bruggeman; Ulrich Reininghaus; Craig Morgan; Robin M Murray; Marta Di Forti; Philip McGuire; Lucia R Valmaggia; Matthew J Kempton; Charlotte Gayer-Anderson; Kathryn Hubbard; Stephanie Beards; Simona A Stilo; Adanna Onyejiaka; Francois Bourque; Gemma Modinos; Stefania Tognin; Maria Calem; Michael C O'Donovan; Michael J Owen; Peter Holmans; Nigel Williams; Nicholas Craddock; Alexander Richards; Isla Humphreys; Andreas Meyer-Lindenberg; F Markus Leweke; Heike Tost; Ceren Akdeniz; Cathrin Rohleder; J Malte Bumb; Emanuel Schwarz; Köksal Alptekin; Alp Üçok; Meram Can Saka; E Cem Atbaşoğlu; Sinan Gülöksüz; Guvem Gumus-Akay; Burçin Cihan; Hasan Karadağ; Haldan Soygür; Eylem Şahin Cankurtaran; Semra Ulusoy; Berna Akdede; Tolga Binbay; Ahmet Ayer; Handan Noyan; Gülşah Karadayı; Elçin Akturan; Halis Ulaş; Celso Arango; Mara Parellada; Miguel Bernardo; Julio Sanjuán; Julio Bobes; Manuel Arrojo; Jose Luis Santos; Pedro Cuadrado; José Juan Rodríguez Solano; Angel Carracedo; Enrique García Bernardo; Laura Roldán; Gonzalo López; Bibiana Cabrera; Sabrina Cruz; Eva Ma Díaz Mesa; María Pouso; Estela Jiménez; Teresa Sánchez; Marta Rapado; Emiliano González; Covadonga Martínez; Emilio Sánchez; Ma Soledad Olmeda; Lieuwe de Haan; Eva Velthorst; Mark van der Gaag; Jean-Paul Selten; Daniella van Dam; Elsje van der Ven; Floor van der Meer; Elles Messchaert; Tamar Kraan; Nadine Burger; Marion Leboyer; Andrei Szoke; Franck Schürhoff; Pierre-Michel Llorca; Stéphane Jamain; Andrea Tortelli; Flora Frijda; Jeanne Vilain; Anne-Marie Galliot; Grégoire Baudin; Aziz Ferchiou; Jean-Romain Richard; Ewa Bulzacka; Thomas Charpeaud; Anne-Marie Tronche; Marc De Hert; Ruud van Winkel; Jeroen Decoster; Catherine Derom; Evert Thiery; Nikos C Stefanis; Gabriele Sachs; Harald Aschauer; Iris Lasser; Bernadette Winklbaur; Monika Schlögelhofer; Anita Riecher-Rössler; Stefan Borgwardt; Anna Walter; Fabienne Harrisberger; Renata Smieskova; Charlotte Rapp; Sarah Ittig; Fabienne Soguel-dit-Piquard; Erich Studerus; Joachim Klosterkötter; Stephan Ruhrmann; Julia Paruch; Dominika Julkowski; Desiree Hilboll; Pak C Sham; Stacey S Cherny; Eric Y H Chen; Desmond D Campbell; Miaoxin Li; Carlos María Romeo-Casabona; Aitziber Emaldi Cirión; Asier Urruela Mora; Peter Jones; James Kirkbride; Mary Cannon; Dan Rujescu; Ilaria Tarricone; Domenico Berardi; Elena Bonora; Marco Seri; Thomas Marcacci; Luigi Chiri; Federico Chierzi; Viviana Storbini; Mauro Braca; Maria Gabriella Minenna; Ivonne Donegani; Angelo Fioritti; Daniele La Barbera; Caterina Erika La Cascia; Alice Mulè; Lucia Sideli; Rachele Sartorio; Laura Ferraro; Giada Tripoli; Fabio Seminerio; Anna Maria Marinaro; Patrick McGorry; Barnaby Nelson; G Paul Amminger; Christos Pantelis; Paulo R Menezes; Cristina M Del-Ben; Silvia H Gallo Tenan; Rosana Shuhama; Mirella Ruggeri; Sarah Tosato; Antonio Lasalvia; Chiara Bonetto; Elisa Ira; Merete Nordentoft; Marie-Odile Krebs; Neus Barrantes-Vidal; Paula Cristóbal; Thomas R Kwapil; Elisa Brietzke; Rodrigo A Bressan; Ary Gadelha; Nadja P Maric; Sanja Andric; Marina Mihaljevic; Tijana Mirjanic Journal: Schizophr Bull Date: 2014-05-24 Impact factor: 9.306