Literature DB >> 26968421

Robotic Primary RPLND for Stage I Testicular Cancer: a Review of Indications and Outcomes.

Heather J Chalfin1, Wesley Ludwig2, Phillip M Pierorazio2, Mohamad E Allaf2.   

Abstract

Patients diagnosed with stage I non-seminomatous germ cell tumor (NSGCT) face the task of selecting a management strategy. Whereas these options all offer excellent survival, unfortunately, each has drawbacks. Retroperitoneal lymph node dissection (RPLND) is a major operation with low, but significant risks of bleeding, chylous ascites, and retrograde ejaculation. Platinum-based chemotherapy is associated with a number of long-term side effects, not all of which are quantified, but include secondary malignancy and early cardiovascular disease. While surveillance minimizes the chances of exposure to unnecessary treatment, it is not infrequently salvaged with chemotherapy and requires a compliant patient willing to undergo serial imaging often with ionizing radiation. Although fewer than one-third of patients will relapse without intervention, the current guidelines propose treatment for stage I patients with high-risk features. New developments in minimally invasive techniques may mitigate the harms of RPLND and avoid the side effects of chemotherapy, making it an ideal option for this cohort of patients. Unlike laparoscopic RPLND, which was introduced as a staging procedure and heavily criticized for the advanced skill set required to achieve oncologic equivalence, robotic RPLND may offer the benefits of a minimally invasive technique without a steep learning curve and a true therapeutic operation in experienced hands.

Entities:  

Keywords:  Minimally invasive; RPLND; Robotics; Testis cancer

Mesh:

Year:  2016        PMID: 26968421     DOI: 10.1007/s11934-016-0597-z

Source DB:  PubMed          Journal:  Curr Urol Rep        ISSN: 1527-2737            Impact factor:   3.092


  44 in total

1.  Laparoscopic retroperitoneal lymph node dissection: description of the nerve-sparing technique.

Authors:  Reinhard Peschel; Matthew T Gettman; Richard Neururer; Alfred Hobisch; Georg Bartsch
Journal:  Urology       Date:  2002-08       Impact factor: 2.649

2.  Increasing incidence of testicular germ cell tumors among black men in the United States.

Authors:  Katherine A McGlynn; Susan S Devesa; Barry I Graubard; Philip E Castle
Journal:  J Clin Oncol       Date:  2005-08-20       Impact factor: 44.544

Review 3.  Role of surgery in management of germ cell tumor.

Authors:  J Sheinfeld; H W Herr
Journal:  Semin Oncol       Date:  1998-04       Impact factor: 4.929

4.  Optimal management of clinical stage I nonseminoma: new data for patients to consider.

Authors:  Ronald de Wit
Journal:  J Clin Oncol       Date:  2014-09-29       Impact factor: 44.544

5.  Long-term renal function after treatment for malignant germ-cell tumours.

Authors:  S D Fosså; N Aass; M Winderen; O P Börmer; D R Olsen
Journal:  Ann Oncol       Date:  2002-02       Impact factor: 32.976

6.  A comparative analysis of robotic vs laparoscopic retroperitoneal lymph node dissection for testicular cancer.

Authors:  Kelly T Harris; Michael A Gorin; Mark W Ball; Phillip M Pierorazio; Mohamad E Allaf
Journal:  BJU Int       Date:  2015-05-25       Impact factor: 5.588

7.  Laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous testicular carcinoma: long-term outcome.

Authors:  G Janetschek; A Hobisch; R Peschel; A Hittmair; G Bartsch
Journal:  J Urol       Date:  2000-06       Impact factor: 7.450

8.  Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors.

Authors:  Pei Dong; Zhuo-Wei Liu; Xiang-Dong Li; Yong-Hong Li; Kai Yao; Song Wu; Zi-Ke Qin; Hui Han; Fang-Jian Zhou
Journal:  Med Oncol       Date:  2013-02-12       Impact factor: 3.064

9.  Testicular cancer in Europe and the USA: survival still rising among older patients.

Authors:  R H A Verhoeven; A Gondos; M L G Janssen-Heijnen; K U Saum; D H Brewster; B Holleczek; E Crocetti; S Rosso; T Hakulinen; T Aareleid; H Brenner
Journal:  Ann Oncol       Date:  2012-10-30       Impact factor: 32.976

Review 10.  Global incidence and outcome of testicular cancer.

Authors:  Thurkaa Shanmugalingam; Aspasia Soultati; Simon Chowdhury; Sarah Rudman; Mieke Van Hemelrijck
Journal:  Clin Epidemiol       Date:  2013-10-17       Impact factor: 4.790

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  4 in total

Review 1.  Current controversies on the role of retroperitoneal lymphadenectomy for testicular cancer.

Authors:  Roy Mano; Renzo Di Natale; Joel Sheinfeld
Journal:  Urol Oncol       Date:  2018-11-13       Impact factor: 3.498

2.  Collaborating with our adult colleagues: A case series of robotic surgery for suspicious and cancerous lesions in children and young adults performed in a free-standing children's hospital.

Authors:  Briony K Varda; Patricia Cho; Andrew A Wagner; Richard S Lee
Journal:  J Pediatr Urol       Date:  2018-03-02       Impact factor: 1.830

3.  Population-based analysis of cost and peri-operative outcomes between open and robotic primary retroperitoneal lymph node dissection for germ cell tumors.

Authors:  Raj Bhanvadia; Caleb Ashbrook; Aditya Bagrodia; Yair Lotan; Vitaly Margulis; Solomon Woldu
Journal:  World J Urol       Date:  2020-08-14       Impact factor: 4.226

4.  Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease.

Authors:  Joost M Blok; J Martijn Kerst; Erik Vegt; Oscar R Brouwer; Richard P Meijer; J L H Ruud Bosch; Axel Bex; Henk G van der Poel; Simon Horenblas
Journal:  BJU Int       Date:  2019-03-28       Impact factor: 5.588

  4 in total

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