BACKGROUND: Understanding sources of variation in International Parkinson and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) scores is essential for planning clinical trials in Parkinson's disease and interpreting studies of mild parkinsonian signs. METHODS: We describe the characteristics of the MDS-UPDRS in a population-based sample of individuals without parkinsonism. Multiple linear regression and Spearman's rank correlation coefficients were used to examine potential associations. RESULTS: Among 194 consecutive individuals without parkinsonism, the mean total MDS-UPDRS score was 12.5 (SD 9.8). Sixty-nine percent (134/193) had motor examination (Part III) scores of 2 or more, 16% (30/194) had scores of 10 or more. Female sex, arthritis or spondylosis, diabetes mellitus, and essential tremor were found to be associated with statistically significant increases in MDS-UPDRS Part III scores. For every 10-year increase in age, the Part III score was greater on average by 2.2 (1.5-2.8). CONCLUSIONS: Elevated MDS-UPDRS scores are common in the general population. The overall burden of motor signs of parkinsonism is especially high in older age groups, in women, and in those with particular comorbidities. Whether this represents evidence of a subclinical neurodegenerative process or the effect of comorbid conditions requires further examination.
BACKGROUND: Understanding sources of variation in International Parkinson and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) scores is essential for planning clinical trials in Parkinson's disease and interpreting studies of mild parkinsonian signs. METHODS: We describe the characteristics of the MDS-UPDRS in a population-based sample of individuals without parkinsonism. Multiple linear regression and Spearman's rank correlation coefficients were used to examine potential associations. RESULTS: Among 194 consecutive individuals without parkinsonism, the mean total MDS-UPDRS score was 12.5 (SD 9.8). Sixty-nine percent (134/193) had motor examination (Part III) scores of 2 or more, 16% (30/194) had scores of 10 or more. Female sex, arthritis or spondylosis, diabetes mellitus, and essential tremor were found to be associated with statistically significant increases in MDS-UPDRS Part III scores. For every 10-year increase in age, the Part III score was greater on average by 2.2 (1.5-2.8). CONCLUSIONS: Elevated MDS-UPDRS scores are common in the general population. The overall burden of motor signs of parkinsonism is especially high in older age groups, in women, and in those with particular comorbidities. Whether this represents evidence of a subclinical neurodegenerative process or the effect of comorbid conditions requires further examination.
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Authors: Ronald B Postuma; Alex Iranzo; Michele Hu; Birgit Högl; Bradley F Boeve; Raffaele Manni; Wolfgang H Oertel; Isabelle Arnulf; Luigi Ferini-Strambi; Monica Puligheddu; Elena Antelmi; Valerie Cochen De Cock; Dario Arnaldi; Brit Mollenhauer; Aleksandar Videnovic; Karel Sonka; Ki-Young Jung; Dieter Kunz; Yves Dauvilliers; Federica Provini; Simon J Lewis; Jitka Buskova; Milena Pavlova; Anna Heidbreder; Jacques Y Montplaisir; Joan Santamaria; Thomas R Barber; Ambra Stefani; Erik K St Louis; Michele Terzaghi; Annette Janzen; Smandra Leu-Semenescu; Guiseppe Plazzi; Flavio Nobili; Friederike Sixel-Doering; Petr Dusek; Frederik Bes; Pietro Cortelli; Kaylena Ehgoetz Martens; Jean-Francois Gagnon; Carles Gaig; Marco Zucconi; Claudia Trenkwalder; Ziv Gan-Or; Christine Lo; Michal Rolinski; Philip Mahlknecht; Evi Holzknecht; Angel R Boeve; Luke N Teigen; Gianpaolo Toscano; Geert Mayer; Silvia Morbelli; Benjamin Dawson; Amelie Pelletier Journal: Brain Date: 2019-03-01 Impact factor: 13.501
Authors: Daniel A Barone; Fei Wang; Lisa Ravdin; Mary Vo; Andrea Lee; Harini Sarva; Natalie Hellmers; Ana C Krieger; Claire Henchcliffe Journal: Clin Park Relat Disord Date: 2020-02-22