Literature DB >> 26965857

New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa.

Fan Yang1, Ru-Ping Wang2, Bin Xu1, Hao-Bing Yu1, Guo-Yi Ma3, Guang-Fei Wang1, Shu-Wen Dai1, Wei Zhang1, Wei-Hua Jiao1, Shao-Jiang Song4, Hou-Wen Lin5.   

Abstract

Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antimalarial; Diacarnus megaspinorhabdosa; Norterpene cyclic peroxide

Mesh：

Substances：

Year:  2016        PMID： 26965857     DOI： 10.1016/j.bmcl.2016.02.070

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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4.  Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review.

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Review 6.  Promising antiparasitic agents from marine sponges.

Authors:  Osama Mostafa; Mohammed Al-Shehri; Mahmoud Moustafa
Journal:  Saudi J Biol Sci       Date:  2021-08-26       Impact factor: 4.219

Review 7.  Marine Terpenic Endoperoxides.

Authors:  Irene Torres-García; Josefa L López-Martínez; Manuel Muñoz-Dorado; Ignacio Rodríguez-García; Miriam Álvarez-Corral
Journal:  Mar Drugs       Date:  2021-11-25       Impact factor: 5.118
  7 in total

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