Mustafa Hatipoglu1, Mesut Mutluoglu2, Vedat Turhan3, Gunalp Uzun4, Benjamin A Lipsky5, Erol Sevim6, Hayati Demiraslan7, Esma Eryilmaz7, Cem Ozuguz8, Ali Memis2, Hakan Ay2, Bilgin Arda9, Serhat Uysal9, Vicdan Koksaldi Motor10, Cigdem Kader11, Ayse Erturk12, Omer Coskun13, Fazilet Duygu14, Selma Guler15, Fatma Aybala Altay16, Aziz Ogutlu17, Sibel Bolukcu18, Senol Yildiz4, Ozlem Kandemir19, Halide Aslaner20, Arife Polat20, Mustafa K Karahocagil21, Kadriye Kart Yasar22, Emine Sehmen23, Sirri Kilic23, Mustafa Sunbul24, Serap Gencer25, Fatma Bozkurt26, Tugba Yanik24, Nefise Oztoprak27, Ayse Batirel25, Hamdi Sozen28, Inci Kilic29, Ilhami Celik29, Bengisu Ay30, Selma Tosun30, Ayten Kadanali31, Senol Çomoglu31, Affan Denk32, Salih Hosoglu26, Ozlem Aydin33, Nazif Elaldi34, Serife Akalin35, Bahar Kandemir36, Ayhan Akbulut32, Tuna Demirdal37, Recep Balik37, Emel Azak38, Gonul Sengoz39. 1. Department of Infectious Diseases and Clinical Microbiology, Canakkale Military Hospital, Canakkale, Turkey. 2. Department of Underwater and Hyperbaric Medicine, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Uskudar, Turkey. 3. Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey. 4. Department of Underwater and Hyperbaric Medicine, Gulhane Military Medical Academy, Ankara, Turkey. 5. Service of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Division of Medical Sciences, Green Templeton College, University of Oxford, Oxford, UK. 6. Department of Infectious Diseases and Clinical Microbiology, Sifa University Medical Faculty Izmir, Turkey. 7. Department of Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey. 8. Department of Infectious Diseases and Clinical Microbiology, Eskisehir Military Hospital, Eskisehir, Turkey. 9. Department of Infectious Diseases and Clinical Microbiology, Ege University School of Medicine, Izmir, Turkey. 10. Department of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University Medical School, Hatay, Turkey. 11. Department of Infectious Diseases and Clinical Microbiology, Bozok University School of Medicine, Yozgat, Turkey. 12. Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey. 13. Department of Infectious Diseases and Clinical Microbiology, Gulhane Medical Academy, Ankara, Turkey. 14. Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpasa University Medical School, Tokat, Turkey. 15. Department of Infectious Diseases and Clinical Microbiology, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey. 16. Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Training & Research Hospital, Ankara, Turkey. 17. Department of Infectious Diseases and Clinical Microbiology, Sakarya University School of Medicine, Sakarya, Turkey. 18. Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. 19. Department of Infectious Diseases and Clinical Microbiology, Mersin University School of Medicine, Mersin, Turkey. 20. Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital Ankara, Turkey. 21. Department of Infectious Diseases and Clinical Microbiology, Yuzuncuyil University School of Medicine, Van, Turkey. 22. Department of Infectious Diseases and Clinical Microbiology Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey. 23. Department of Infectious Diseases and Clinical Microbiology, Samsun Training and Research Hospital Samsun, Turkey. 24. Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey. 25. Department of Infectious Diseases and Clinical Microbiology, Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey. 26. Department of Infectious Diseases and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey. 27. Department of Infectious Diseases and Clinical Microbiology, Antalya Education and Research Hospital, Antalya, Turkey. 28. Department of Infectious Disease, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey. 29. Department of Infectious Disease, Education and Research Hospital, Kayseri, Turkey. 30. Department of Infectious Diseases and Clinical Microbiology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey. 31. Department of Infectious Diseases and Clinical Microbiology, Umraniye Training and Research Hospital, Istanbul, Turkey. 32. Department of Infectious Diseases and Clinical Microbiology, Firat University School of Medicine, Elazig, Turkey. 33. Department of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey. 34. Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Medical School, Sivas, Turkey. 35. Department of Infectious Diseases and Clinical Microbiology, Pamukkale University School of Medicine, Denizli, Turkey. 36. Department of Infectious Diseases and Clinical Microbiology, Necmettin Erbakan University, Konya, Turkey. 37. Department of Infectious Diseases and Clinical Microbiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey. 38. Department of Infectious Diseases, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. 39. Department of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, Istanbul, Turkey.
Abstract
AIM: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. METHODS: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). RESULTS: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. CONCLUSIONS: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions.
AIM: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. METHODS: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). RESULTS: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. CONCLUSIONS: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions.
Authors: Vanessa Silva; Cecília Peirone; Rosa Capita; Carlos Alonso-Calleja; José A Marques-Magallanes; Isabel Pires; Luís Maltez; José Eduardo Pereira; Gilberto Igrejas; Patrícia Poeta Journal: Biology (Basel) Date: 2021-04-26
Authors: Oryan Henig; Jason M Pogue; Raymond Cha; Paul E Kilgore; Umar Hayat; Mahmoud Ja'ara; Raza Muhamad Ali; Salman Mahboob; Rahul Pansare; Kathryn Deeds; Bushra Joarder; Hyndavi Kandala; Sorabh Dhar; Keith S Kaye Journal: Open Forum Infect Dis Date: 2018-09-27 Impact factor: 3.835