AIMS: To analyze changes in telomere length (TL) after dialysis initiation. METHODS: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. RESULTS: Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (x0394;TL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (x03C1; = -0.70, p < 0.0001) and leukocyte count (x03C1; = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with x0394;TL. CONCLUSIONS: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.
AIMS: To analyze changes in telomere length (TL) after dialysis initiation. METHODS: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. RESULTS: Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (x0394;TL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (x03C1; = -0.70, p < 0.0001) and leukocyte count (x03C1; = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with x0394;TL. CONCLUSIONS: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.
Authors: S Hägg; Y Zhan; R Karlsson; L Gerritsen; A Ploner; S J van der Lee; L Broer; J Deelen; R E Marioni; A Wong; A Lundquist; G Zhu; N K Hansell; E Sillanpää; I O Fedko; N A Amin; M Beekman; A J M de Craen; S Degerman; S E Harris; K-J Kan; C M Martin-Ruiz; G W Montgomery; A N Adolfsson; C A Reynolds; N J Samani; H E D Suchiman; A Viljanen; T von Zglinicki; M J Wright; J-J Hottenga; D I Boomsma; T Rantanen; J A Kaprio; D R Nyholt; N G Martin; L Nyberg; R Adolfsson; D Kuh; J M Starr; I J Deary; P E Slagboom; C M van Duijn; V Codd; N L Pedersen Journal: Transl Psychiatry Date: 2017-04-18 Impact factor: 6.222