| Literature DB >> 26958831 |
Haotian Lin1, Hong Ouyang1, Jie Zhu2, Shan Huang1, Zhenzhen Liu1, Shuyi Chen1, Guiqun Cao3, Gen Li3,4, Robert A J Signer5, Yanxin Xu3,6, Christopher Chung2, Ying Zhang7, Danni Lin2, Sherrina Patel2, Frances Wu2, Huimin Cai3,4, Jiayi Hou8, Cindy Wen2, Maryam Jafari2, Xialin Liu1, Lixia Luo1, Jin Zhu2, Austin Qiu2, Rui Hou4, Baoxin Chen1, Jiangna Chen1, David Granet2, Christopher Heichel2, Fu Shang1, Xuri Li1, Michal Krawczyk2, Dorota Skowronska-Krawczyk2, Yujuan Wang1, William Shi2, Daniel Chen2, Zheng Zhong1,2, Sheng Zhong2, Liangfang Zhang2, Shaochen Chen2, Sean J Morrison5, Richard L Maas7, Kang Zhang1,2,3,9, Yizhi Liu1.
Abstract
The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We design a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells.Entities:
Mesh：
Substances：
Year: 2016 PMID： 26958831 PMCID： PMC6061995 DOI： 10.1038/nature17181
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962