Daniel Mumpe-Mwanja1, Suzanne Verver2, Adoke Yeka3, Alfred Etwom4, James Waako5, Willy Ssengooba6, Joseph Kb Matovu7, Rhoda K Wanyenze8, Phillipa Musoke9, Harriet Mayanja-Kizza10. 1. Makerere University School of Public Health, CDC fellowship program; Makerere University, Iganga Mayuge Health Demographic Surveillance Site; Makerere University College of Health Sciences, Infectious Diseases Institute; Ministry of Health, National Tuberculosis and Leprosy Program. 2. KNCV Tuberculosis Foundation; CINIMA, Academic Medical Centre. 3. Makerere University School of Public Health, Department of Disease control and Environmental Health. 4. Ministry of Health, National Tuberculosis and Leprosy Program. 5. Makerere University, Iganga Mayuge Health Demographic Surveillance Site; Makerere University College of Health Sciences, Infectious Diseases Institute. 6. Makerere University School of Medicine, Department of Microbiology; Makerere University College of Health Sciences, Infectious Diseases Institute. 7. Makerere University School of Public Health, CDC fellowship program. 8. Makerere University School of Public Health, CDC fellowship program; Makerere University School of Public Health, Department of Disease control and Environmental Health. 9. Makerere University College of Health Sciences, Infectious Diseases Institute; Makerere University School of Medicine, Department of Pediatrics and Child Health. 10. Makerere University School of Medicine, Department of Medicine; Makerere University College of Health Sciences, Infectious Diseases Institute.
Abstract
BACKGROUND: Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy. OBJECTIVES: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda. METHODS: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression. RESULTS: The prevalence of latent TB was 16.1%, 95% CI (15.1 - 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 - 1.48); male gender, APR 1.37 (95% CI 1.21 - 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 - 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 - 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 - 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 - 2.35). CONCLUSION: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.
BACKGROUND:Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy. OBJECTIVES: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda. METHODS: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression. RESULTS: The prevalence of latent TB was 16.1%, 95% CI (15.1 - 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 - 1.48); male gender, APR 1.37 (95% CI 1.21 - 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 - 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 - 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 - 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 - 2.35). CONCLUSION: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.
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