Literature DB >> 26956792

The use of fluorescently-tagged apoptolidins in cellular uptake and response studies.

Katherine M Chong1,2, Nalin Leelatian1,3, Sean M Deguire1,2, Asa A Brockman3, David Earl1,2, Rebecca A Ihrie2,3, Jonathan M Irish1,3, Brian O Bachmann1,4, Gary A Sulikowski1,4.   

Abstract

The apoptolidins are glycomacrolide microbial metabolites reported to be selectively cytotoxic against tumor cells. Using fluorescently tagged active derivatives we demonstrate selective uptake of these four tagged glycomacrolides in cancer cells over healthy human blood cells. We also demonstrate the utility of these five fluorescently tagged glycomacrolides in fluorescent flow cytometry to monitor cellular uptake of the six glycomacrolides and cellular response.

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Year:  2016        PMID： 26956792      PMCID： PMC5518790          DOI： 10.1038/ja.2016.22

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  23 in total

1.  Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples.

Authors:  Peter O Krutzik; Angelica Trejo; Kenneth R Schulz; Garry P Nolan
Journal:  Methods Mol Biol       Date:  2011

2.  Isolation, structure determination, and anti-cancer activity of apoptolidin D.

Authors:  Paul A Wender; Kate E Longcore
Journal:  Org Lett       Date:  2007-02-15       Impact factor: 6.005

3.  Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.

Authors:  J W Kim; H Adachi; K Shin-ya; Y Hayakawa; H Seto
Journal:  J Antibiot (Tokyo)       Date:  1997-07       Impact factor: 2.649

4.  Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.

Authors:  Yu Du; Dagmara K Derewacz; Sean M Deguire; Jesse Teske; Jacques Ravel; Gary A Sulikowski; Brian O Bachmann
Journal:  Tetrahedron       Date:  2011-09-02       Impact factor: 2.457

5.  Flow cytometric assessment of the cellular pharmacokinetics of fluorescent drugs.

Authors:  M S Dordal; A C Ho; M Jackson-Stone; Y F Fu; C L Goolsby; J N Winter
Journal:  Cytometry       Date:  1995-08-01

Review 6.  Apoptolidin: induction of apoptosis by a natural product.

Authors:  Peter T Daniel; Ulrich Koert; Julia Schuppan
Journal:  Angew Chem Int Ed Engl       Date:  2006-01-30       Impact factor: 15.336

7.  Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.

Authors:  A R Salomon; D W Voehringer; L A Herzenberg; C Khosla
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

8.  Apoptolidin A: total synthesis and partially glycosylated analogues.

Authors:  Hermut Wehlan; Mario Dauber; M Teresa Mujica Fernaud; Julia Schuppan; Sonja Keiper; Rainer Mahrwald; M-Elisa Juarez Garcia; Ulrich Koert
Journal:  Chemistry       Date:  2006-09-25       Impact factor: 5.236

9.  The disaccharide moiety of bleomycin facilitates uptake by cancer cells.

Authors:  Benjamin R Schroeder; M Imran Ghare; Chandrabali Bhattacharya; Rakesh Paul; Zhiqiang Yu; Paul A Zaleski; Trevor C Bozeman; Michael J Rishel; Sidney M Hecht
Journal:  J Am Chem Soc       Date:  2014-09-23       Impact factor: 15.419

10.  The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting.

Authors:  Chandrabali Bhattacharya; Zhiqiang Yu; Michael J Rishel; Sidney M Hecht
Journal:  Biochemistry       Date:  2014-05-13       Impact factor: 3.162
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