Yukihiro Horie1, Akira Meguro2, Tohru Ohta3, Eun Bong Lee4, Kenichi Namba5, Kazuomi Mizuuchi5, Daiju Iwata5, Nobuhisa Mizuki2, Masao Ota6, Hidetoshi Inoko7, Susumu Ishida5, Shigeaki Ohno5, Nobuyoshi Kitaichi1,5. 1. a Department of Ophthalmology , Health Sciences University of Hokkaido , Sapporo , Japan. 2. b Department of Ophthalmology and Visual Science , Yokohama City University Graduate School of Medicine , Yokohama , Japan. 3. c Research Institute of Personalized Heath Sciences, Health Sciences University of Hokkaido , Tobetsu , Japan. 4. d Department of Internal Medicine and Graduate Program in Immunology , Medical Research Center, Seoul National University Hospital , Seoul , Korea. 5. e Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan. 6. f Department of Legal Medicine , Shinshu University School of Medicine , Matsumoto , Japan. 7. g Department of Molecular Life Science , Tokai University School of Medicine , Isehara , Japan.
Abstract
PURPOSE: Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups. METHODS: A literature survey was conducted, and 18 articles written in English were reviewed. RESULTS: A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BD patients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east. CONCLUSIONS: A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD.
PURPOSE: Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups. METHODS: A literature survey was conducted, and 18 articles written in English were reviewed. RESULTS: A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BDpatients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east. CONCLUSIONS: A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD.